Cetirizine Impurity D
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| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Cetirizine Impurity D is an impurity of Cetirizine. Cetirizine is a second-generation antihistamine that acts as a specific, orally active, and long-acting antagonist of the histamine H1-receptor. Cetirizine exhibits antiallergic properties and inhibits eosinophil chemotaxis in response to allergies.
CAS:
346451-15-8
Molecular Weight:
487.46
Purity:
0.98
SMILES:
ClC1=CC=C(C=C1)C(C=2C=CC=CC2)N3CCN(CC3)C(C=4C=CC=CC4)C5=CC=C(Cl)C=C5
References
Shimizu T, et al. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004 Jan;34(1):103-9.
Shih MY, et al. Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells. Allergy Asthma Proc. 2008 Sep-Oct;29(5):480-5.
Caroline M. Spencer, et al. Cetirizine. Drugs 46 (6): 1055-1080, 1993.