Pexidartinib hydrochloride
| Code | Size | Price |
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| TAR-T62788-2g | 2g | £870.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, selective, orally active, ATP-competitive inhibitor of colony-stimulating factor 1 (CSF1R or M-CSFR) (IC50: 20 nM) and c-Kit (IC50: 10 nM). Pexidartinib hydrochloride is 10-100 times more selective for c-Kit and CSF1R than for other related kinases, acting on FLT3 (IC50: 160 nM), KDR (VEGFR2) (IC50: 350 nM), LCK (IC50: 860 nM), FLT1 (VEGFR1) (Pexidartinib hydrochloride induces apoptosis and exhibits anti-tumour effects.
CAS:
2040295-03-0
Molecular Weight:
454.28
Purity:
0.98
SMILES:
Cl.FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1