Anti-Human/Mouse integrin β7 - Purified in vivo GOLD™ Functional Grade
| Code | Size | Price |
|---|
| LEI-F1196-1mg | 1 mg | £167.00 |
Quantity:
| LEI-F1196-5mg | 5 mg | £330.00 |
Quantity:
| LEI-F1196-25mg | 25 mg | £733.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2a κ
Antibody Clonality: Monoclonal
Antibody Clone: FIB27
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Blocking
- Flow Cytometry
- In Vivo Assay
Shipping:
2-8°C
Storage:
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Further Information
Antigen Distribution:
Integrin β7 heterodimer α4/β7 is expressed on peripheral lymphocytes, thymocytes and bone marrow progenitors. Integrin β7 heterodimer αE/β7 is expressed on intestinal IEL, dendritic epidermal T cells, T regulatory cells, CD8+ T cells in lymph nodes and lamina propria.
Concentration:
? 5.0 mg/ml
Conjugate/Tag/Label:
in vivo GOLD™, Purified in vivo Functional Grade
Format:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Immunogen:
TK1 cells
Long Description:
Integrin β7 is a 130 kD highly flexible membrane protein in the Ig superfamily that plays a role in lymphocyte adhesion. This flexibility facilitates a dynamic affinity for ligand via conformational changes. Integrin β7 forms heterodimers with α4 or αE (ITGAE) for structural stability. The α4/β7 heterodimer, also known as LPAM-1, binds to VCAM-1, MAdCAM-1 and fibronectin. The αE/β7 heterodimer interacts with E-Cadherin. Integrin β7 interacts with EED.
Purity:
?95% monomer by analytical SEC, >95% by SDS Page
Target:
Integrin Beta 7
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