Dichlone
| Code | Size | Price |
|---|
| CDX-D0641-M100 | 100 mg | £63.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
Short term: +20°C. Long term: +20°C
Documents
Further Information
Alternate Names/Synonyms:
2,3-Dichloro-1,4-naphthoquinone; CNQ; Dichlon; NSC 537; USR 604
Appearance:
White to light yellow powder.
CAS:
117-80-6
EClass:
32160000
Form (Short):
solid
GHS Symbol:
GHS06,GHS09
Handling Advice:
Protect from light and moisture.
Hazards:
H301-H315-H319-H410
InChi:
InChI=1S/C10H4Cl2O2/c11-7-8(12)10(14)6-4-2-1-3-5(6)9(7)13/h1-4H
InChiKey:
SVPKNMBRVBMTLB-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 117-80-6. Formula: C10H4Cl2O2. MW: 227.04. Dichlone is a naphthoquinone derivative and is widely used in various applications, particularly as a pesticide (fungicide and algicide). This compound can be used as an analytical reference. Dichlone shows several biological properties. It is a potent redox mediator, inducing oxidative stress, has been shown to inhibit ryanodine receptors and acts as a potent DNA methylation inhibitor (EC50=460nM against Dnmt3A/3L catalytic complex). Dichlone is also used as an organic catalyst or as chemical intermediate for synthetic procedures (dyes, pigments) or for spectrophotometric analysis of primary aliphatic amines.
MDL:
MFCD00001677
Molecular Formula:
C10H4Cl2O2
Molecular Weight:
227.04
Package Type:
Vial
PG:
III
Precautions:
P264-P270-P273-P301+P310-P302+P352-P305+P351+P338
Product Description:
Dichlone is a naphthoquinone derivative and is widely used in various applications, particularly as a pesticide (fungicide and algicide). This compound can be used as an analytical reference. Dichlone shows several biological properties. It is a potent redox mediator, inducing oxidative stress, has been shown to inhibit ryanodine receptors and acts as a potent DNA methylation inhibitor (EC50=460nM against Dnmt3A/3L catalytic complex). Dichlone is also used as an organic catalyst or as chemical intermediate for synthetic procedures (dyes, pigments) or for spectrophotometric analysis of primary aliphatic amines.
Purity:
>98% (GC)
Signal Word:
Danger
SMILES:
ClC1=C(Cl)C(=O)c2ccccc2C1=O
Solubility Chemicals:
Soluble in chloroform or DMSO.
Source / Host:
Synthetic
Transportation:
Excepted Quantity
UN Nummer:
UN2811
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 6 months after receipt when stored at RT.
References
(1) A.A. Abou-Ouf, et al.; J. Pharm. Sci. 62, 1700 (1973) | (2) H.C. Sikka, et al.; Chem. Biol. Interact. 9, 261 (1974) | (3) C.A. Pritsos, et al.; Arch. Biochem. Biophys. 217, 98 (1982) | (4) F.A. El-Yazbi, et al.; J. Pharm. Biomed. Anal. 19, 819 (1999) | (5) C. Morisseau, et al.; Environ Health Perspect. 117, 1867 (2009) | (6) P.P. Vaughan, et al.; Photochem. Photobiol. 86, 1327 (2010) | (7) A. Ceccaldi, et al.; ACS Chem. Biol. 8, 543 (2013) | (8) T.S. Belal, et al.; Spectrochim. Acta A Mol. Biomol. Spectrosc. 155, 47 (2016) | (9) A.A. Petrova, et al.; FEBS Lett. 592, 2220 (2018)