(+)-Naproxen methyl ester
| Code | Size | Price |
|---|
| CDX-N0557-M050 | 50 mg | £86.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
Short term: +20°C. Long term: +4°C
Documents
Further Information
Alternate Names/Synonyms:
(S)-Naproxen methyl ester; NME; Naproxen Impurity E (PhEur); (2S)-2-(6-Methoxy-2-naphthyl)propionic acid methyl ester; Methyl (2S)-2-(6-Methoxynaphthalen-2-yl)propanoat
Appearance:
White to off-white powder or crystals.
CAS:
26159-35-3
EClass:
32160000
Form (Short):
solid
GHS Symbol:
GHS07,GHS08,GHS09
Handling Advice:
Protect from light and moisture.
Hazards:
H302 - H315 - H319 - H335 - H361fd - H411
InChi:
InChI=1S/C15H16O3/c1-10(15(16)18-3)11-4-5-13-9-14(17-2)7-6-12(13)8-11/h4-10H,1-3H3
InChiKey:
ZFYFBPCRUQZGJE-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 26159-35-3. Formula: C15H16O3. MW: 244.29. The metabolite Naproxen methyl ester (Naproxen Impurity E) is a degradation product from Naproxen which is a non-steroidal anti-inflammatory drug (NSAID) used to in the treatment of pain, menstrual cramps, inflammatory diseases such as rheumatoid arthritis, gout and fever. Ibuprofen is an anti-inflammatory COX inhibitor. This product can be used as a control esterase substrate, as a working standard or secondary analytical reference standard or as an organic building block and intermediate for synthesis.
MDL:
MFCD12031841
Molecular Formula:
C15H16O3
Molecular Weight:
244.29
Package Type:
Vial
PG:
III
Precautions:
P202 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
Product Description:
The metabolite Naproxen methyl ester (Naproxen Impurity E) is a degradation product from Naproxen which is a non-steroidal anti-inflammatory drug (NSAID) used to in the treatment of pain, menstrual cramps, inflammatory diseases such as rheumatoid arthritis, gout and fever. Ibuprofen is an anti-inflammatory COX inhibitor. This product can be used as a control esterase substrate, as a working standard or secondary analytical reference standard or as an organic building block and intermediate for synthesis.
Purity:
>98% (HPLC)
Signal Word:
Warning
SMILES:
C(C(OC)=O)(C)C1=CC2=C(C=C(OC)C=C2)C=C1
Solubility Chemicals:
Soluble in chloroform, methanol or DCM.
Source / Host:
Synthetic
Transportation:
Excepted Quantity
UN Nummer:
UN3077
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) M. Najlah, et al.; Int. J. Pharm. 308, 175 (2006) | (2) H. Weber, et al.; Arch. Pharm. 327, 337 (1994) | (3) C.J. Welch, et al.; J. High Resol. Chromatogr. 20, 179 (1997) | (4) H. Weber, et al.; Pharma. Res. 18, 600 (2001) | (5) J. Krzek & M. Starek; J. Plan. Chromatogr. 17, 137 (2004) | (6) L. Steenkamp & D. Brady; Proc. Biochem. 43, 1419 (2008) | (7) K.C. Duggan, et al.; J. Biol. Chem. 285, 34950 (2010) | (8) R.S. Reddy, et al.; TACL 6, 55 (2016) | (9) I. Cacciatore, et al.; Int. J. Mol. Sci. 17, 1035 (2016) | (10) K. Birgul, et al.; Eur. J. Med. Chem. 208, 112841 (2020)