Abnova Corporation

LBP monoclonal antibody, clone biG 412

Product Code:
 
MAB5663
Product Group:
 
Primary Antibodies
Supplier:
 
Abnova Corporation
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
biG 412
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Enzyme-Linked Immunosorbent Assay (ELISA)
Storage:
 
Store at -20°C on dry atmosphere.
After reconstitution with deionized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.
 

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CodeSizePrice
MAB5663-100ug100 ug£384.00
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Further Information

Antigen Target Species:
Human
Form:
Lyophilized
Gene Alias:
MGC22233
Gene Description:
lipopolysaccharide binding protein
Gene ID:
3929
Gene Name:
LBP
Immunogen:
Recombinant protein corresponding to human LBP.
Product Description:
Mouse monoclonal antibody raised against recombinant LBP.
Recommend Dilutions:
ELISA (1:50000)
The optimal working dilution should be determined by the end user.
Specificity:
LPS binding protein (LBP) is an approximately 60 KDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to a 100-1,000-fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into High Density Lipoprotein (HDL), which effectively neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria.
Storage Buffer:
Lyophilized from PBS

References

  • http://www.ncbi.nlm.nih.gov/pubmed/11680654
  • http://www.ncbi.nlm.nih.gov/pubmed/11874891
  • http://www.ncbi.nlm.nih.gov/pubmed/15128806