CTLA4 monoclonal antibody, clone ANC152.2/8H5

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Abnova Corporation
Product Code: MAB6927
Product Group: Primary Antibodies
CodeSizePrice
MAB6927-100ug100 ug£401.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Isotype: IgG1, kappa
Antibody Clonality: Monoclonal
Antibody Clone: ANC152.2/8H5
Regulatory Status: RUO
Target Species: Human
Applications:
  • Flow Cytometry
  • Immunohistochemistry (IHC)
  • Immunoprecipitation (IP)
Storage:
Store at 4°C.

Documents

Further Information

Antigen Target Species:
Human
Form:
Liquid
Gene Alias:
CD152|CELIAC3|CTLA-4|GSE|IDDM12
Gene Description:
cytotoxic T-lymphocyte-associated protein 4
Gene ID:
1493
Gene Name:
CTLA4
Immunogen:
A mixture of stimulated human PBL's and human CTLA4 Ig fusion protein.
Product Description:
Mouse monoclonal antibody raised against CTLA4.
Recommend Dilutions:
The optimal working dilution should be determined by the end user.
Specificity:
MAB6927 blocks binding of CD152 (CTLA-4) Ig fusion protein to its CD80/CD86 receptor, and has been reported to modulate suppressive function of human T Regulatory cells in Vitro. It can bind to intracellular CD152 in fixed permeabolized cells. The F(ab')2 form has been used to inhibit proliferation of activated T cells in vitro in a cholera toxin model.
Storage Buffer:
In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)

References

  • http://www.ncbi.nlm.nih.gov/pubmed/10878341
  • http://www.ncbi.nlm.nih.gov/pubmed/14978077
  • http://www.ncbi.nlm.nih.gov/pubmed/8760834