Citrullinated Fibrinogen monoclonal antibody, clone 3D1
| Code | Size | Price |
|---|
| MAB5303-100ug | 100 ug | £1,383.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: 2 IgG1
Antibody Clonality: Monoclonal
Antibody Clone: 3D1
Regulatory Status: RUO
Target Species: Mouse
Application: Enzyme-Linked Immunosorbent Assay (ELISA)
Storage:
Store at 4°C.
Documents
Further Information
Antigen Target Species:
Mouse
Form:
Lyophilized
Immunogen:
A synthetic peptide corresponding to mouse Citrullinated Fibrinogen.
Product Description:
Mouse monoclonal antibody raised against synthetic peptide of Citrullinated Fibrinogen.
Recommend Dilutions:
ELISA (1:2000-1:4000)
Immunohistochemistry (1:100-1:500)
Western Blot (1:100-1:500)
The optimal working dilution should be determined by the end user.
Recommended antibody concentration: 0.5 mg/mL.
Immunohistochemistry (1:100-1:500)
Western Blot (1:100-1:500)
The optimal working dilution should be determined by the end user.
Recommended antibody concentration: 0.5 mg/mL.
Specificity:
Fibrinogen is a protein produced by the liver which helps stop bleeding by helping blood clots to form. Fibrinogen gets deiminated (conversion from arginin to citrullin) by Peptidyl Arginine Deiminase (PAD) in inflamed joints in patients that develop rheumatoid arthritis. Citrulline, while being an amino acid, is not built into proteins during protein synthesis, as it is not coded for by DNA, yet several proteins are known to contain citrulline. Proteins that normally contain citrulline residues include myelin basic protein (MBP), filaggrin, and several histone proteins, while other proteins, like fibrin and vimentin can get deiminated during cell death and tissue inflammation. Patients with rheumatoid arthritis often (at least 80% of them) develop an immune response against proteins containing citrulline.
Storage Buffer:
Lyophilized from 10 mM ammonium bicarbonate buffer.