anti-PIDD (human) pAb (AL233)
| Code | Size | Price |
|---|
| AG-25B-0015-C050 | 50 ug | £200.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Immunohistochemistry (IHC)
- Immunoprecipitation (IP)
- Western Blot (WB)
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
p53-induced Protein with a Death Domain; Leucine-rich Repeat and Death Domain-containing Protein; Lrdd
Concentration:
1 mg/ml
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Immunogen:
Recombinant human PIDD (Death Domain: aa 776-910).
Long Description:
Polyclonal Antibody. Recognizes human and the native form of mouse PIDD. Detects bands of ~90kDa (full length protein) and ~50kDa (cleaved protein) by Western blot. Source: Rabbit. Applications: IHC, IP, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. PIDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. It associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. It associates with caspase-2 and RAIDD, and induces activation of caspase-2 which is an important regulator in the apoptotic pathways.
NCBI, Uniprot Number:
Q9HB75
Package Type:
Plastic Vial
Product Description:
PIDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. It associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. It associates with caspase-2 and RAIDD, and induces activation of caspase-2 which is an important regulator in the apoptotic pathways.
Source / Host:
Rabbit
Specificity:
Recognizes human and the native form of mouse PIDD. Detects bands of ~90kDa (Full Length FL-PIDD) and ~50kDa (cleaved protein) by Western blot.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.
References
The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress: A. Tinel & J. Tschopp; Science 304, 843 (2004) | PIDD mediates NF-kB activation in Response to DNA damage: Janssens et al.; Cell 123, 1079 (2005) | Heat shock induces apoptosis independently of any known initiator caspase-activating complex: R.S. Milleron & S.B. Bratton; J. Biol. Chem. 281, 16991 (2006) | An Inhibitor of PIDDosome Formation: R. Thompson, et al.; Mol. Cell 58, 767 (2015) | NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus: K. Ando, et al.; J. Cell Biol. 216, 1795 (2017) | FANCI functions as a repair/apoptosis switch in response to DNA crosslinks: R.B. Shah, et al.; Dev. Cell 56, 1 (2021)