FN14 (human):Fc (human) (rec.) (MultiPack)
| Code | Size | Price |
|---|
| AG-40B-0034-C050 | 50 ug | £210.00 |
Quantity:
| AG-40B-0034-3050 | 3 x 50 ug | £410.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Shipping:
Blue Ice
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Tumor Necrosis Factor Receptor Superfamily Member 12A; FGF-inducible 14; Tweak-receptor; CD266; TNFRSF12A
Concentration:
1mg/ml after reconstitution.
EClass:
32160000
Endotoxin:
<0.1EU/µg purified protein (LAL test; Lonza).
Form (Short):
liquid
Formulation:
Lyophilized. Contains PBS.
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1% BSA should be used for further dilutions.
Long Description:
Protein. The extracellular region of human FN14 (aa 28-75) is fused at the C-terminus to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: <0.1EU/µg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Binds to mouse and human TWEAK. Purity: >95% (SDS-PAGE). TWEAK is a cytokine that controls proliferation, migration, differentiation, apoptosis, angiogenesis and inflammation. TWEAK binds to Fn14, a highly inducible cell-surface receptor that is linked to several intracellular signalling pathways, including the nuclear factor-B (NF-kappaB) pathway. The TWEAK?Fn14 axis plays a beneficial role in tissue repair following acute injury and may contribute to cancer, chronic autoimmune diseases and acute ischaemic stroke.
Molecular Weight:
~35kDa (SDS-PAGE).
NCBI, Uniprot Number:
Q9NP84
Package Type:
Plastic Vial
Product Description:
TWEAK is a cytokine that controls proliferation, migration, differentiation, apoptosis, angiogenesis and inflammation. TWEAK binds to Fn14, a highly inducible cell-surface receptor that is linked to several intracellular signalling pathways, including the nuclear factor-B (NF-kappaB) pathway. The TWEAK?Fn14 axis plays a beneficial role in tissue repair following acute injury and may contribute to cancer, chronic autoimmune diseases and acute ischaemic stroke.
Purity:
>95% (SDS-PAGE)
Sequence:
The extracellular region of human FN14 (aa 28-75) is fused at the C-terminus to the Fc portion of human IgG1.
Source / Host:
HEK 293 cells
Specificity:
Binds to mouse and human TWEAK.
TAGs:
Fc
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
References
No evidence that soluble TACI induces signalling via membrane-expressed BAFF and APRIL in myeloid cells: J. Nys, et al.; PLoS One 8, e61350 (2013)