TRAIL-R1 (human):Fc (human) (rec.) (MultiPack)

DR4; TNFRSF 10A; APO2; CD261; TRAIL Receptor 1; TNF-related Apoptosis-inducing Ligand Receptor 1

Blocks human or mouse TRAIL activity in a concentration of 1-10µg/ml.

1mg/ml after reconstitution.

32160000

<0.01EU/µg purified protein (LAL test; Lonza).

liquid

Lyophilized. Contains PBS.

After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1% BSA should be used for further dilutions.

Protein. The extracellular domain of human TRAIL-R1 (aa 24-239) is fused to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: <0.01EU/µg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Binds to human and mouse TRAIL. Purity: >95% (SDS-PAGE). TRAIL-R1 (DR4; CD261) is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.

~52kDa (SDS-PAGE)

O00220

Plastic Vial

TRAIL-R1 (DR4; CD261) is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.

>95% (SDS-PAGE)

The extracellular domain of human TRAIL-R1 (aa 24-239) is fused to the Fc portion of human IgG1.

HEK 293 cells

Binds to human and mouse TRAIL.

Fc

Non-hazardous

Other Proteins

12352202

Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.