Anomalin A
Product Code: AG-CN2-0006
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0006-M001 | 1 mg | £110.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
2,3,6,8-Tetrahydroxy-1-methylxanthone
Appearance:
Yellowish solid.
CAS:
548740-86-9
EClass:
32160000
Form (Short):
solid
Handling Advice:
Protect from light.
InChi:
InChI=1S/C14H10O6/c1-5-11-10(4-8(17)13(5)18)20-9-3-6(15)2-7(16)12(9)14(11)19/h2-4,15-18H,1H3
InChiKey:
YPBXGIBBOZOVPM-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 548740-86-9. Formula: C14H10O6. MW: 274.1. Isolated from marine fungus Arthrinium sp. Lck (p56lck; lymphocyte specific tyrosine kinase) inhibitor. Antioxidant. DPPH radical scavenger.
MDL:
MFCD19381839
Molecular Formula:
C14H10O6
Molecular Weight:
274.1
Package Type:
Vial
Product Description:
Antiproliferative agent against selected cancer cell lines. Inhibits protein kinases ALK, ARK5, Aurora-B, AXL, FAK, IGF1-R, MET, PIM1, PLK1, PRK1, SRC, and VEGF-R2 with IC50 values between 0.3 and 75.7µM, most probably contributing to the antiproliferative activity. Shown to inhibit VEGF-A dependent endothelial cells sprouting with IC50 value of 1.8µM corresponding to its in vitro inhibitory activity against VEGF-R2 protein kinase (IC50=0.8µM). Lck (p56lck; lymphocyte specific tyrosine kinase) inhibitor. Antioxidant. DPPH radical scavenger.
Purity:
>97% (HPLC)
SMILES:
[H]C1=C(O)C(O)=C(C)C2=C1OC1=C(C(O)=CC(O)=C1)C2=O
Solubility Chemicals:
Soluble in 100% ethanol or DMSO.
Source / Host:
Isolated from marine fungus Arthrinium sp.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Two new xanthone derivatives from the algicolous marine fungus Wardomyces anomalus: A. Abdel-Lateff, et al.; J. Nat. Prod. 66, 706 (2003) | Arthrinins A?D: Novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.: S.S. Ebada, et al.; Bioorg. Med. Chem. 19, 4644 (2011)