Pifithrin-alpha . hydrobromide
| Code | Size | Price |
|---|
| AG-CR1-0004-M005 | 5 mg | £50.00 |
Quantity:
| AG-CR1-0004-M010 | 10 mg | £80.00 |
Quantity:
| AG-CR1-0004-M025 | 25 mg | £150.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone . HBr, Pfithrin alpha
Appearance:
White to off-white solid.
CAS:
63208-82-2
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep under inert gas.Protect from light.
InChi:
InChI=1S/C16H18N2OS.BrH/c1-11-6-8-12(9-7-11)14(19)10-18-13-4-2-3-5-15(13)20-16(18)17;/h6-9,17H,2-5,10H2,1H3;1H
InChiKey:
HAGVCKULCLQGRF-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 63208-82-2. Formula: C16H18N2OS . HBr. MW: 286.4 . 80.9. p53 inhibitor. Reversibly blocks p53-dependent transcriptional activation. Tool to combat side effects of cancer therapy. Apoptosis inhibitor.
MDL:
MFCD00417851
Molecular Formula:
C16H18N2OS . HBr
Molecular Weight:
286.4 . 80.9
Package Type:
Vial
Product Description:
p53 inhibitor [1, 2]. Reversibly blocks p53-dependent transcriptional activation [2]. Tool to combat side effects of cancer therapy [3]. Apoptosis inhibitor [1, 2, 4].
Purity:
>98% (HPLC + NMR)
SMILES:
[Br].CC1=CC=C(C=C1)C(=O)CN1C(=N)SC2=C1CCCC2
Solubility Chemicals:
Soluble in DMSO or 100% ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy: P.G. Komarov, et al.; Science 285, 1733 (1999) | Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation: P.J. Murphy, et al.; J. Biol. Chem. 279, 30195 (2004) | Cancer research. A new way to combat therapy side effects: D. Ferber; Science 285, 1651 (1999) | Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio: D. Javelaud & F. Besancon; J. Biol. Chem. 277, 37949 (2002) | Loss of Fragile X Protein FMRP Impairs Homeostatic Synaptic Downscaling through Tumor Suppressor p53 and Ubiquitin E3 Ligase Nedd4-2: K.Y. Lee, et al.; Hum. Mol. Genet. ahead of print (2018) | Novel roles of ER stress in repressing neural activity and seizures through Mdm2- and p53-dependent protein translation: D.C. Liu, et al.; PLoS Genetics 15, e1008364 (2019)