Compound 34
| Code | Size | Price |
|---|
| AG-CR1-0007-C200 | 200 ug | £85.00 |
Quantity:
| AG-CR1-0007-M001 | 1 mg | £230.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
(2S,3R)-3-(3,4-Difluorophenyl)-2-(4-fluorophenyl)-4-hydroxy-N-((3S)-2-oxo-5-phenyl-2,3-1H-benzo[e][1,4]diazepin-3-yl)butyramide
Appearance:
White to off-white powder.
CAS:
564462-36-8
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Hygroscopic.Protect from light.
InChi:
InChI=1S/C31H24F3N3O3/c32-21-13-10-18(11-14-21)27(23(17-38)20-12-15-24(33)25(34)16-20)30(39)37-29-31(40)35-26-9-5-4-8-22(26)28(36-29)19-6-2-1-3-7-19/h1-16,23,27,29,38H,17H2,(H,35,40)(H,37,39)/t23-,27+,29+/m0/s1
InChiKey:
JFRCHOZGXWZLOQ-TZIIFLTASA-N
Long Description:
Chemical. CAS: 564462-36-8. Formula: C31H24F3N3O3. MW: 543.5. Cell permeable, highly potent inhibitor of gamma-secretase (IC50 = 0.06 nM).
MDL:
MFCD08702692
Molecular Formula:
C31H24F3N3O3
Molecular Weight:
543.5
Package Type:
Vial
Product Description:
Cell permeable, highly potent inhibitor of gamma-secretase (IC50 = 0.06 nM) [1].
Purity:
>98% (NMR)
SMILES:
OC[C@H]([C@H](C(=O)N[C@H]1N=C(C2=CC=CC=C2)C2=C(NC1=O)C=CC=C2)C1=CC=C(F)C=C1)C1=CC=C(F)C(F)=C1
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by use of an asymmetric Ireland-Claisen rearrangement: I. Churcher, et al.; J. Med. Chem 46 2275 (2003)
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