FK-866
| Code | Size | Price |
|---|
| AG-CR1-0011-M001 | 1 mg | £45.00 |
Quantity:
| AG-CR1-0011-M005 | 5 mg | £105.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Blue Ice
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
K 22.175; FK866; APO866; WK175; N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2E-propenamide
Appearance:
White to yellow solid. (Tends to easily liquefy.)
CAS:
658084-64-1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Hygroscopic.Keep under inert gas.
Hazards:
H302, H315, H319, H335
InChi:
InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+
InChiKey:
KPBNHDGDUADAGP-VAWYXSNFSA-N
Long Description:
Chemical. CAS: 658084-64-1. Formula: C24H29N3O2. MW: 391.5. Nampt/visfatin inhibitor. Inhibitor of NAD+ biosynthesis. Inhibits the enzyme/substrate complex and the free enzyme (Ki = 0.4 nM and Ki = 0.3 nM, respectively). Apoptosis inducer. Autophagy inducer. Causes premature senescence. Angiogenesis inhibitor.
MDL:
MFCD10565943
Molecular Formula:
C24H29N3O2
Molecular Weight:
391.5
Package Type:
Vial
Precautions:
P261, P271, P280, P312
Product Description:
Nampt/visfatin inhibitor [1]. Inhibitor of NAD+ biosynthesis [1]. Inhibits the enzyme/substrate complex and the free enzyme (Ki = 0.4 nM and Ki = 0.3 nM, respectively) [1]. Apoptosis inducer [1]. Autophagy inducer [2]. Causes premature senescence [3]. Angiogenesis inhibitor [4].
Purity:
>98% (NMR)
Signal word:
Warning
SMILES:
O=C(NCCCCC1CCN(CC1)C(=O)C1=CC=CC=C1)C=CC1=CC=CN=C1
Solubility Chemicals:
Soluble in 100% ethanol, dimethylformamide (40 mg/ml) or DMSO (25 mg/ml); sparingly soluble in aqueous buffers.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis: M. Hasmann & I. Schemainda; Cancer Res. 63, 7436 (2003) | NAD depletion by FK866 induces autophagy: R.A. Billington, et al.; Autophagy 4, 385 (2008) | Extension of human cell lifespan by nicotinamide phosphoribosyltransferase: E. van der Veer, et al.; J. Biol. Chem. 282, 10841 (2007) | Antiangiogenic potency of FK866/K22.175, a new inhibitor of intracellular NAD biosynthesis, in murine renal cell carcinoma: J. Drevs, et al.; Anticancer Res. 23, 4853 (2003) | Nicotinamide phosphoribosyltransferase production in human spermatozoa is influenced by maturation stage: S. Riammer, et al.; Andrology 4, 1045 (2016) | Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis: L. Brandl, et al.; Neoplasia 21, 974 (2019)