SNC80
| Code | Size | Price |
|---|
| AG-CR1-0017-M005 | 5 mg | £65.00 |
Quantity:
| AG-CR1-0017-M025 | 25 mg | £230.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
4°C
Documents
Further Information
Alternate Names/Synonyms:
(+)-4-[(alphaR)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide
Appearance:
White to off-white crystalline solid.
CAS:
156727-74-1
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27-/m1/s1
InChiKey:
KQWVAUSXZDRQPZ-UMTXDNHDSA-N
Long Description:
Chemical. CAS: 156727-74-1. Formula: C28H39N3O2. MW: 449.6. Highly selective and potent non-peptide delta-opioid receptor agonist. Mediates downregulation of the delta-opioid receptor. Shows antidepressant-like effects. Modulates voltage-dependent sodium channels. Antinociceptive. Activates ATP-sensitive K+ channels. Enhances amphetamine-mediated dopamine efflux.
MDL:
MFCD00672673
Molecular Formula:
C28H39N3O2
Molecular Weight:
449.6
Package Type:
Vial
Product Description:
Highly selective and potent non-peptide delta-opioid receptor agonist [1-3]. Mediates downregulation of the delta-opioid receptor [4]. Shows antidepressant-like effects [5, 8]. Modulates voltage-dependent sodium channels [6]. Antinociceptive [7]. Activates ATP-sensitive K+ channels [7]. Enhances amphetamine-mediated dopamine efflux [9].
Purity:
>99% (NMR)
SMILES:
[H][C@@](N1C[C@@H](C)N(CC=C)C[C@@H]1C)(C1=CC=C(C=C1)C(=O)N(CC)CC)C1=CC(OC)=CC=C1
Solubility Chemicals:
Soluble in 100% ethanol, DMSO or dichloromethane.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4- [(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist: S.N. Calderon, et al.; J. Med. Chem. 37, 2125 (1994) | SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist: E.J. Bilsky, et al.; J. Pharmacol. Exp. Ther. 273, 359 (1995) | Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors: R.J. Knapp|et al.; J. Pharmacol. Exp. Ther. 277, 1284 (1996) | Differential down-regulation of the human delta-opioid receptor by SNC80 and [D-Pen(2),D-Pen(5)]enkephalin: T. Okura, et al.; Eur. J. Pharmacol. 387, R11 (2000) | Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents: A. Saitoh, et al.; J. Pharmacol. Sci. 95, 374 (2004) | Modulation of voltage-dependent sodium channels by the delta-agonist SNC80 in acutely isolated rat hippocampal neurons: C. Remy, et al.; Neuropharmacology 47, 1102 (2004) | Delta-opioid receptor agonist SNC80 induces peripheral antinociception via activation of ATP-sensitive K+ channels: D.F. Pacheco & I.D. Duarte; Eur. J. Pharmacol. 512, 23 (2005) | Antidepressant-like effects of the delta-opioid receptor agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in an olfactory bulbectomized rat model: A. Saitoh, et al.; Brain Res. 1208, 160 (2008) | The selective delta opioid agonist SNC80 enhances amphetamine-mediated efflux of dopamine from rat striatum: K.E. Bosse, et al.; Neuropharmacology 55, 755 (2008)