MK-571 . sodium salt
| Code | Size | Price |
|---|
| AG-CR1-0021-M005 | 5 mg | £50.00 |
Quantity:
| AG-CR1-0021-M025 | 25 mg | £170.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Blue Ice
Storage:
-20°C
Documents
Further Information
Appearance:
Light yellow solid.
CAS:
115103-85-0 | 115104-28-4 (free base)
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Hygroscopic.Protect from light.
Hazards:
H315, H319, H335
InChi:
InChI=1S/C26H27ClN2O3S2.Na/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22;/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32);/q;+1/p-1/b10-6+;
InChiKey:
XNAYQOBPAXEYLI-AAGWESIMSA-M
Long Description:
Chemical. CAS: 115103-85-0 | 115104-28-4 (free base). Formula: C26H26ClN2O3S2 . Na. MW: 514.1 . 23.0. Selective leukotriene LTD4 receptor antagonist. Potent MRP1 inhibitor. Antinociceptive.
MDL:
MFCD00878420
Molecular Formula:
C26H26ClN2O3S2 . Na
Molecular Weight:
514.1 . 23.0
Other data:
Aqueous stock solutions may be stable for more than 24 hours but we recommend making a fresh preparation before use.
Package Type:
Vial
Precautions:
P261, P271, P280, P312
Product Description:
Selective leukotriene LTD4 receptor antagonist [1]. Potent multidrug resistance-associated protein MRP1 and MRP2 inhibitor [2,4]. Antinociceptive [3].
Purity:
>97% (NMR)
Signal word:
Warning
SMILES:
[Na+].CN(C)C(=O)CCSC(SCCC([O-])=O)C1=CC(C=CC2=CC=C3C=CC(Cl)=CC3=N2)=CC=C1
Solubility Chemicals:
Soluble in water (20 mg/ml), 100% ethanol (10 mg/ml), DMSO or methanol.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist: T.R. Jones, et al.; Can. J. Physiol. Pharmacol. 67, 17 (1989) | The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance: V. Gekeler, et al.; BBRC 208, 345 (1995) | The antinociceptive effect of leukotriene D(4) receptor antagonist, MK-571, in mice: possible involvement of opioidergic mechanism: Eur. J. Pharmacol. 386, 195 (1999) | Inhibition of Glucose Transport by Tomatoside A, a Tomato Seed Steroidal Saponin, through the Suppression of GLUT2 Expression in Caco-2 Cells: J. Agric. Food Chem. ahead of print 2018