MTEP
| Code | Size | Price |
|---|
| AG-CR1-0022-M005 | 5 mg | £75.00 |
Quantity:
| AG-CR1-0022-M025 | 25 mg | £270.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
4°C
Documents
Further Information
Alternate Names/Synonyms:
3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine
Appearance:
Light yellow solid.
CAS:
329205-68-7
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light.
InChi:
InChI=1S/C11H8N2S/c1-9-13-11(8-14-9)5-4-10-3-2-6-12-7-10/h2-3,6-8H,1H3
InChiKey:
NRBNGHCYDWUVLC-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 329205-68-7. Formula: C11H8N2S. MW: 200.3. Potent and selective antagonist for mGluR5. 5-fold higher anxiolytic activity than MPEP. Antidepressant. Neuroprotective. Produces antiparkinsonian-like effects in rats.
MDL:
MFCD04974585
Molecular Formula:
C11H8N2S
Molecular Weight:
200.3
Package Type:
Vial
Product Description:
Potent and selective antagonist for mGluR5 [1, 2]. 5-fold higher anxiolytic activity than MPEP [3]. Antidepressant [4]. Neuroprotective [5]. Produces antiparkinsonian-like effects in rats [6].
Purity:
>98% (NMR)
SMILES:
CC1=NC(=CS1)C#CC1=CC=CN=C1
Solubility Chemicals:
Soluble in DMSO, 100% ethanol or methanol.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity: J. Med. Chem. 46 204 (2003) | Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling: A. Klodzinska, et al.; Neuropharmacology 47, 342 (2004) | Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP: P.M. Lea IV & A.I. Faden; CNS Drug Rev. 12, 149 (2006) | Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist: A. Palucha, et al.; Pharmacol. Biochem. Behav. 81, 901 (2005) | Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors: P.M.t. Lea, et al.; Br. J. Pharmacol. 145, 527 (2005) | MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats: K. Ossowska, et al.; Neuropharmacology 49, 447 (2005)