MnTMPyP . pentachloride
| Code | Size | Price |
|---|
| AG-CR1-0026-M010 | 10 mg | £35.00 |
Quantity:
| AG-CR1-0026-M050 | 50 mg | £85.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Manganese (III) tetrakis (1-methyl-4-pyridyl)porphyrin . 5Cl-
Appearance:
Black solid.
CAS:
100012-18-8
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C44H36N8.Mn/c1-49-21-13-29(14-22-49)41-33-5-7-35(45-33)42(30-15-23-50(2)24-16-30)37-9-11-39(47-37)44(32-19-27-52(4)28-20-32)40-12-10-38(48-40)43(36-8-6-34(41)46-36)31-17-25-51(3)26-18-31;/h5-28H,1-4H3;/q2*+2
InChiKey:
YFSTUYRXNOTFMB-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 100012-18-8. Formula: C44H36MnN8Cl5. MW: 909. Cell permeable superoxide dismutase (SOD) mimetic. Peroxynitrite scavenger. Displays a protective effect against H2O2 mediated injury. Neuroprotective. Oxidative stress inhibitor. Apoptosis inhibitor. Reduces inflammation.
Molecular Formula:
C44H36MnN8Cl5
Molecular Weight:
909
Other data:
Prepare solutions immediately before experiments. We recommend using fresh preparations each day.
Package Type:
Vial
Product Description:
Cell permeable superoxide dismutase (SOD) mimetic [1, 2, 4]. Peroxynitrite scavenger [3]. Displays a protective effect against H2O2 mediated injury [5]. Neuroprotective [6]. Oxidative stress inhibitor [7]. Apoptosis inhibitor [7]. Reduces inflammation [8].
Purity:
>96% (Microanalysis)
SMILES:
C[N+]1=CC=C(C=C1)C1=C2C=CC3=[N]2C24N5C1=CC=C5C(=C1C=CC(C(=C5C=CC(N25)=C3C2=CC=[N+](C)C=C2)C2=CC=[N+](C)C=C2)=[N]41)C1=CC=[N+](C)C=C1
Solubility Chemicals:
Soluble in aqueous base.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo: K.M. Faulkner, et al.; J. Biol. Chem. 269, 23471 (1994) | Superoxide scavenging by Mn(II/III) tetrakis (1-methyl-4-pyridyl) porphyrin in mammalian cells: P.R. Gardner, et al.; Arch. Biochem. Biophys. 325, 20 (1996) | Molecular actions of a Mn(III)Porphyrin superoxide dismutase mimetic and peroxynitrite scavenger: reaction with nitric oxide and direct inhibition of NO synthase and soluble guanylyl cyclase: S. Pfeiffer, et al.; Mol. Pharmacol. 53, 795 (1998) | The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium- 2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic: Batinic-Haberle, et al.; J. Biol. Chem. 273, 24521 (1998) | Protective properties of tin- and manganese-centered porphyrins against hydrogen peroxide-mediated injury in rat astroglial cells: B.E. Dwyer, et al.; J. Neurochem. 71, 2497 (1998) | Neuroprotective effect of MnTMPyP, a superoxide dismutase/catalase mimetic in global cerebral ischemia is mediated through reduction of oxidative stress and DNA fragmentation: S.S. Sharma & S. Gupta; Eur. J. Pharmacol. 561, 72 (2007) | MnTMPyP, a cell-permeant SOD mimetic, reduces oxidative stress and apoptosis following renal ischemia-reperfusion: H.L. Liang, et al.; Am. J. Physiol. Renal Physiol. 296, F266 (2009) | MnTMPyP, a superoxide dismutase/catalase mimetic, decreases inflammatory indices in ischemic acute kidney injury: J. Mortensen, et al.; Inflamm. Res. 60, 299 (2011)