SB202190
| Code | Size | Price |
|---|
| AG-CR1-0028-M001 | 1 mg | £36.00 |
Quantity:
| AG-CR1-0028-M005 | 5 mg | £60.00 |
Quantity:
| AG-CR1-0028-M025 | 25 mg | £100.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
FHPI; 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole
Appearance:
Off-white solid.
CAS:
152121-30-7
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light.
Hazards:
H315, H319, H335
InChi:
InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)
InChiKey:
QHKYPYXTTXKZST-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 152121-30-7. Formula: C20H14FN3O. MW: 331.3. Potent and cell permeable p38 MAP kinase inhibitor. Apoptosis inducer. Inhibits p38alpha and beta, but not gamma and delta isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. JNK activator. Autophagic vacuole inducer
MDL:
MFCD00941964
Molecular Formula:
C20H14FN3O
Molecular Weight:
331.3
Package Type:
Vial
Precautions:
P261, P271, P280, P312
Product Description:
Potent and cell permeable p38 MAP kinase inhibitor [1, 2]. Apoptosis inducer [3]. Inhibits p38alpha and beta, but not gamma and delta isoforms [4, 5]. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators [6]. JNK activator [7]. Autophagic vacuole inducer [8]
Purity:
>97% (HPLC)
Signal word:
Warning
SMILES:
OC1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=NC=C1)C1=CC=C(F)C=C1
Solubility Chemicals:
Soluble in methanol, DMSO or acetone; slightly soluble in ethyl acetate.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis: J.C. Lee, et al.; Nature 372, 739 (1994) | SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRNAs in monocytes: C.L Manthey, et al.; J. Leukoc. Biol. 64, 409 (1998) | Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase: S. Nemoto, et al.; J. Biol. Chem. 273, 16415 (1998) | Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta): Y. Jiang, et al.; J. Biol. Chem. 271, 17920 (1996) | The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase: K.P. Wilson, et al.; Chem. Biol. 4, 423 (1997) | A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase: T. Fox, et al.; Protein Sci. 7, 2249 (1998) | Activation of c-Jun N-terminal kinase (JNK) by widely used specific p38 MAPK inhibitors SB202190 and SB203580: a MLK-3-MKK7-dependent mechanism: H. Muniyappa & K.C. Das; Cell. Signal. 20, 675 (2008) | SB202190-induced cell type-specific vacuole formation and defective autophagy do not depend on p38 MAP kinase inhibition: MB. Menon, et al.; PLos One 6, e23054 (2011) | A preliminary study on the proinflammatory mechanisms of Treponema pallidum outer membrane protein Tp92 in human macrophages and HMEC-1 cells: X. Luo, et al.; Microb. Pathog. 110, 176 (2017) | Candida albicans infection disturbs redox homeostasis system and induces reactive oxygen species accumulation for epithelial cell death: T. Ren, et al.; FEMS Yeast Res. ahead of print (2019) | Signaling pathways involved in anti-inflammatory effects of Pulsed Electromagnetic Field in microglial cells: S. Merighi, et al.; Cytokine 125, 154777 (2020)