SB366791
| Code | Size | Price |
|---|
| AG-CR1-0034-M005 | 5 mg | £55.00 |
Quantity:
| AG-CR1-0034-M025 | 25 mg | £190.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
N-(3-Methoxyphenyl)-4-chlorocinnamide
Appearance:
White to beige crystalline solid.
CAS:
472981-92-3
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C16H14ClNO2/c1-20-15-4-2-3-14(11-15)18-16(19)10-7-12-5-8-13(17)9-6-12/h2-11H,1H3,(H,18,19)/b10-7+
InChiKey:
RYAMDQKWNKKFHD-JXMROGBWSA-N
Long Description:
Chemical. CAS: 472981-92-3. Formula: C16H14ClNO2. MW: 287.8. Potent and selective TRPV1 antagonist. Glutamatergic synaptic transmission inhibitor.
MDL:
MFCD01033818
Molecular Formula:
C16H14ClNO2
Molecular Weight:
287.8
Other data:
Solutions are stable for up to 3 months when stored at -20°C.
Package Type:
Vial
Product Description:
Potent and selective TRPV1 antagonist [1, 2]. Glutamatergic synaptic transmission inhibitor [3].
Purity:
>99% (NMR)
SMILES:
COC1=CC=CC(NC(=O)C=CC2=CC=C(Cl)C=C2)=C1
Solubility Chemicals:
Soluble in 100% ethanol (warm) or DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist: M.J. Gunthorpe, et al.; Neuropharmacology 46, 133 (2004) | Effects of the novel TRPV1 receptor antagonist SB366791 in vitro and in vivo in the rat: A. Varga, et al.; Neurosci. Lett. 385, 137 (2005) | TRPV1 antagonist, SB-366791, inhibits glutamatergic synaptic transmission in rat spinal dorsal horn following peripheral inflammation: S.C. Lappin, et al.; Eur. J. Pharmacol. 540, 73 (2006) | Heat induces interleukin-6 in skeletal muscle cells via TRPV1/PKC/CREB pathways: S. Obi, et al.; J. Appl. Physiol. 122, 683 (2017) | Heat induces myogenic transcription factors of myoblast cells via transient receptor potential vanilloid 1 (Trpv1): S. Obi, et al.; FEBS Open Bio (2018)