AMI-1
| Code | Size | Price |
|---|
| AG-CR1-0038-M005 | 5 mg | £75.00 |
Quantity:
| AG-CR1-0038-M025 | 25 mg | £270.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Arginine N-methyltransferase inhibitor-1
Appearance:
Brown solid.
CAS:
160994-87-6 (xNa)134-47-4 (free base)
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.Hygroscopic.Protect from light.
Hazards:
H315, H319, H335
InChi:
InChI=1S/C21H16N2O9S2.4Na/c24-19-9-15(33(27,28)29)7-11-5-13(1-3-17(11)19)22-21(26)23-14-2-4-18-12(6-14)8-16(10-20(18)25)34(30,31)32;;;;/h1-10,24-25H,(H2,22,23,26)(H,27,28,29)(H,30,31,32);;;;/q;4*+1/p-4
InChiKey:
OEJIOAHFKHHDAW-UHFFFAOYSA-J
Long Description:
Chemical. CAS: 20324-87-2134-47-4 (free base). Formula: C21H12N2O9S2Na4. MW: 592.4. Potent, cell permeable and specific protein arginine N-methyltransferase 1 (PRMT1) inhibitor (IC50 = 8.8 µM). Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site. Blocks peptide substrate binding. HIV-1 RT polymerase inhibitor (IC50 = 5.0 µM).
MDL:
MFCD00035715
Molecular Formula:
C21H12N2O9S2Na4
Molecular Weight:
592.4
Package Type:
Vial
Precautions:
P261, P271, P280, P312
Product Description:
Potent, cell permeable and specific protein arginine N-methyltransferase 1 (PRMT1) inhibitor (IC50 = 8.8 µM) [1]. Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site [1]. Blocks peptide substrate binding [3]. HIV-1 RT polymerase inhibitor (IC50 = 5.0 µM) [2].
Purity:
>99% (NMR)
Signal word:
Warning
SMILES:
[Na+].[Na+].[O-]C1=CC(=CC2=C1C=CC(NC(=O)NC1=CC3=C(C=C1)C([O-])=CC(=C3)S(=O)(=O)O[Na])=C2)S(=O)(=O)O[Na]
Solubility Chemicals:
Soluble in water, 100% ethanol or DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Small molecule regulators of protein arginine methyltransferases: D. Cheng, et al.; J. Biol. Chem. 279, 23892 (2004) | A novel mechanism for inhibition of HIV-1 reverse transcriptase: A.G. Skillman, et al.; Bioorg. Chem. 30, 443 (2002) | Inhibitory study of protein arginine methyltransferase 1 using a fluorescent approach: Y. Feng, et al.; BBRC 379, 567 (2009)
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