Pifithrin-alpha (cyclic) . hydrobromide
| Code | Size | Price |
|---|
| AG-CR1-0052-M005 | 5 mg | £62.00 |
Quantity:
| AG-CR1-0052-M010 | 10 mg | £100.00 |
Quantity:
| AG-CR1-0052-M050 | 50 mg | £360.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole . HBr; beta-Pifithrin; PFT-beta; QB102
Appearance:
White to off-white solid.
CAS:
511296-88-160477-34-1 (free base)
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep under inert gas.Protect from light.Protect from moisture.
InChi:
InChI=1S/C16H16N2S.BrH/c1-11-6-8-12(9-7-11)13-10-18-14-4-2-3-5-15(14)19-16(18)17-13;/h6-10H,2-5H2,1H3;1H
InChiKey:
SGNCOAOESGSEOP-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 511296-88-160477-34-1 (free base). Formula: C16H16N2S . HBr. MW: 268.4 . 80.9. Stable analog of pifithrin-alpha. p53 inhibitor.
MDL:
MFCD02683960
Molecular Formula:
C16H16N2S . HBr
Molecular Weight:
268.4 . 80.9
Package Type:
Vial
Product Description:
Stable analog of pifithrin-alpha [1]. p53 inhibitor [1, 2].
Purity:
>98% (HPLC)
SMILES:
[Br].CC1=CC=C(C=C1)C1=CN2C(SC3=C2CCCC3)=N1
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Novel cyclized Pifithrin-alpha p53 inactivators: synthesis and biological studies: Bioorg. Med. Chem. Lett. 15, 1561 (2005) | Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism: N. Pietrancosta, et al.; J. Med. Chem. 49, 3645 (2006) | Loss of Fragile X Protein FMRP Impairs Homeostatic Synaptic Downscaling through Tumor Suppressor p53 and Ubiquitin E3 Ligase Nedd4-2: K.Y. Lee, et al.; Hum. Mol. Genet. ahead of print (2018)