Sirtinol
| Code | Size | Price |
|---|
| AG-CR1-0055-M001 | 1 mg | £35.00 |
Quantity:
| AG-CR1-0055-M005 | 5 mg | £60.00 |
Quantity:
| AG-CR1-0055-M025 | 25 mg | £160.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
+4°C
Storage:
4°C
Documents
Further Information
Alternate Names/Synonyms:
Sir Two Inhibitor Naphthol; 2-[(2-Hydroxynaphthalen-1-yl-methylene)amino]-N-(1-phenethyl)benzamide
Appearance:
Off-white to yellow solid.
CAS:
410536-97-9
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light.
InChi:
InChI=1S/C26H22N2O2/c1-18(19-9-3-2-4-10-19)28-26(30)22-13-7-8-14-24(22)27-17-23-21-12-6-5-11-20(21)15-16-25(23)29/h2-18,29H,1H3,(H,28,30)/b27-17+
InChiKey:
UXJFDYIHRJGPFS-WPWMEQJKSA-N
Long Description:
Chemical. CAS: 410536-97-9. Formula: C26H22N2O2. MW: 394.5. Specific cell permeable SIRT1 (sirtuin 1) inhibitor. Senescence-like growth arrest inducer. Platelet aggregation inhibitor. Apoptosis inducer.
MDL:
MFCD00810186
Molecular Formula:
C26H22N2O2
Molecular Weight:
394.5
Other data:
Relatively unstable in aqueous solution, especially at acidic pH.
Package Type:
Vial
Product Description:
Specific cell permeable SIRT1 (sirtuin 1) inhibitor [1, 2]. Senescence-like growth arrest inducer [3]. Platelet aggregation inhibitor [4]. Apoptosis inducer [5].
Purity:
>98% (NMR)
SMILES:
CC(NC(=O)C1=C(C=CC=C1)N=CC1=C(O)C=CC2=C1C=CC=C2)C1=CC=CC=C1
Solubility Chemicals:
Soluble in DMSO, 100% ethanol or dimethyl formamide.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening: C.M. Grozinger, et al.; J. Biol. Chem. 276, 38837 (2001) | Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors: A. Mai, et al.; J. Med. Chem. 48, 7789 (2005) | Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells: H. Ota, et al.; Oncogene 25, 176 (2006) | A new insight of anti-platelet effects of sirtinol in platelets aggregation via cyclic AMP phosphodiesterase: F.C. Liu, et al.; Biochem. Pharmacol. 77, 1364 (2009) | SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2: B. Peck, et al.; Mol. Cancer Ther. 9, 844 (2010)