PD 150,606
| Code | Size | Price |
|---|
| AG-CR1-0066-M005 | 5 mg | £70.00 |
Quantity:
| AG-CR1-0066-M025 | 25 mg | £250.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic acid
Appearance:
Off-white solid.
CAS:
426821-41-2
Class:
6.1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS05,GHS06
Handling Advice:
Keep under inert gas.Protect from light.
Hazards:
H301, H315, H317, H318, H335
InChi:
InChI=1S/C9H7IO2S/c10-7-3-1-6(2-4-7)5-8(13)9(11)12/h1-5,13H,(H,11,12)/b8-5-
InChiKey:
DJCVSFWGKYHMKH-YVMONPNESA-N
Long Description:
Chemical. CAS: 426821-41-2. Formula: C9H7IO2S. MW: 306.1. Cell permeable and selective calpain-1 and -2 inhibitor. Interacts with calcium-binding domain of calpain. Neuroprotective. Ca2+-permeable AMPA receptor inhibitor. Apoptosis inhibitor Autophagy activator by preventing cleavage of ATG5
MDL:
MFCD00949076
Molecular Formula:
C9H7IO2S
Molecular Weight:
306.1
Package Type:
Vial
PG:
III
Precautions:
P261, P271, P280, P301, P312, P302, P352, P333, P313
Product Description:
Cell permeable and selective calpain-1 and -2 inhibitor [1, 3]. Interacts with calcium-binding domain of calpain [2, 4]. Neuroprotective [2]. Ca2+-permeable AMPA receptor inhibitor [5]. Apoptosis inhibitor [6] Autophagy activator by preventing cleavage of ATG5 [7.]
Purity:
>98% (NMR)
Signal word:
Danger
SMILES:
OC(=O)C(S)=CC1=CC=C(I)C=C1
Solubility Chemicals:
Soluble in DMSO or methanol.
Transportation:
Excepted Quantity
UN Nummer:
UN 2811
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Modulation of hypoxia-induced calpain activity in rat renal proximal tubules: C.L. Edelstein, et al.; Kidney Int. 50, 1150 (1996) | An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective: K.K. Wang, et al.; PNAS 93, 6687 (1996) | Alpha-mercaptoacrylic acid derivatives as novel selective calpain inhibitors: K.K. Wang, et al.; Adv. Exp. Med. Biol. 389, 95 (1996) | Crystal structure of calcium bound domain VI of calpain at 1.9A resolution and its role in enzyme assembly, regulation, and inhibitor binding: G.D. Lin, et al.; Nat. Struct. Biol. 4, 539 (1997) | An alpha-mercaptoacrylic acid derivative (PD150606) inhibits selective motor neuron death via inhibition of kainate-induced Ca2+ influx and not via calpain inhibition: L. Van den Bosch, et al.; Neuropharmacology 42, 706 (2002) | Calpain, an upstream regulator of thymocyte apoptosis: M.K. Squier & J.J. Cohen; J. Immunol. 158, 3690 (1997) | Post-translational control of IL-1beta via the human papillomavirus type 16 E6 oncoprotein: a novel mechanism of innate immune escape mediated by the E3-ubiquitin ligase E6-AP and p53: M. Niebler, et al.; PLoS Pathog. 9, e1003536 (2013)