MnTBAP chloride
| Code | Size | Price |
|---|
| AG-CR1-0133-M010 | 10 mg | £30.00 |
Quantity:
| AG-CR1-0133-M050 | 50 mg | £75.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Manganese (III) tetrakis (4-benzoic acid)porphyrin chloride
Appearance:
Black crystalline powder.
CAS:
55266-18-7
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C48H30N4O8.ClH.Mn/c53-45(54)29-9-1-25(2-10-29)41-33-17-19-35(49-33)42(26-3-11-30(12-4-26)46(55)56)37-21-23-39(51-37)44(28-7-15-32(16-8-28)48(59)60)40-24-22-38(52-40)43(36-20-18-34(41)50-36)27-5-13-31(14-6-27)47(57)58;;/h1-24,33,38H,(H,53,54)(H,55,56)(H,57,58)(H,59,60);1H;/q-4;;+7/p-1/b41-34-,42-35-,43-36-,44-40-;;
InChiKey:
APHAGHGOUIMDLD-SAHKUQKESA-M
Long Description:
Chemical. CAS: 55266-18-7. Formula: C48H28MnN4O8Cl. MW: 879.2. Cell permeable superoxide dismutase (SOD) mimetic. Potent inhibitor of peroxynitrite-induced oxidative reactions (peroxynitrite scavenger), but not a scavenger of nitric oxide (NO). Neuronal apoptosis inhibitor. Protects T cells from superoxide generation, caspase-dependent DNA loss and cell death. Lipopolysaccharide-induced TNF-alpha production inhibitor, by prevention of intracellular ROS generation and subsequent inactivation of p38 MAPK and SAPK/JNK. .
MDL:
MFCD06227760
Molecular Formula:
C48H28MnN4O8Cl
Molecular Weight:
879.2
Package Type:
Vial
Product Description:
Cell permeable superoxide dismutase (SOD) mimetic [1, 2]. Potent inhibitor of peroxynitrite-induced oxidative reactions (peroxynitrite scavenger), but not a scavenger of nitric oxide (NO) [3]. Neuronal apoptosis inhibitor [4]. Protects T cells from superoxide generation, caspase-dependent DNA loss and cell death [5]. Lipopolysaccharide-induced TNF-alpha production inhibitor, by prevention of intracellular ROS generation and subsequent inactivation of p38 MAPK and SAPK/JNK [6]. .
Purity:
>97%
SMILES:
[Cl-].OC(=O)C1=CC=C(C=C1)C1=C2C=CC3=C(C4C=CC5=C(C6=CC=C7N6[Mn+3](N6C1C=CC6=C7C1=CC=C(C=C1)C(O)=O)(N45)N23)C1=CC=C(C=C1)C(O)=O)C1=CC=C(C=C1)C(O)=O
Solubility Chemicals:
Dissolve at 0.1M in aqueous base, then add buffer to lower pH to pH 7.0 or higher as needed.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo: K.M. Faulkner, et al.; J. Biol. Chem. 269, 23471 (1994) | A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro: B.J. Day, et al.; J. Pharm. Exp. Ther. 275,1227 (1995) | Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger: C. Szabe;, et al.; FEBS Lett. 381, 82 (1996) | Inhibition of neuronal apoptosis by a metalloporphyrin superoxide dismutase mimic: M. Patel; J. Neurochem. 71, 1068 (1998) | Reactive oxygen species regulate activation-induced T cell apoptosis: D.A. Hildeman, et al.; Immunity 10, 735 (1999) | MnTBAP, a synthetic metalloporphyrin, inhibits production of tumor necrosis factor-alpha in lipopolysaccharide-stimulated RAW 264.7 macrophages cells via inhibiting oxidative stress-mediating p38 and SAPK/JNK signaling: G. Tumurkhuu, et al.; FEMS Immunol. Med. Microbiol. 49, 304 (2007) | Regulation of Beclin 1 protein phosphorylation and autophagy by protein phosphatase 2A (PP2A) and death-associated protein kinase 3 (DAPK3): N. Fujiwara, et al.; J. Biol. Chem. 291, 10858 (2016)