BIX 01294 . trihydrochloride
| Code | Size | Price |
|---|
| AG-CR1-0150-M001 | 1 mg | £34.00 |
Quantity:
| AG-CR1-0150-M005 | 5 mg | £60.00 |
Quantity:
| AG-CR1-0150-M025 | 25 mg | £210.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]4-quinazolinamine . 3HCl
Appearance:
White to off-white solid.
CAS:
1392399-03-9 | 935693-62-2 (free base)
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep under inert gas.Protect from light.
InChi:
1S/C28H38N6O2.3ClH/c1-32-12-7-13-34(17-16-32)28-30-24-19-26(36-3)25(35-2)18-23(24)27(31-28)29-22-10-14-33(15-11-22)20-21-8-5-4-6-9-21;;;/h4-6,8-9,18-19,22H,7,10-17,20H2,1-3H3,(H,29,30,31);3*1H
InChiKey:
FMURUEPQXKJIPS-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1392399-03-9 | 935693-62-2 (free base). Formula: C28H38N6O2 . 3HCl. MW: 490.6 . 109.4. Selective and cell permeable G9a histone-lysine methyltransferase (HMTase) inhibitor. Does not compete with cofactor S-adenosylmethionine. Pluripotent stem cell inducer.
MDL:
MFCD16618384
Molecular Formula:
C28H38N6O2 . 3HCl
Molecular Weight:
490.6 . 109.4
Package Type:
Vial
Product Description:
Selective and cell permeable G9a histone-lysine methyltransferase (HMTase) inhibitor [1]. Does not compete with cofactor S-adenosylmethionine [1]. Pluripotent stem cell inducer [2, 3].
Purity:
>98% (NMR, HPLC)
SMILES:
COC1=C(OC)C=C2C(NC3CCN(CC4=CC=CC=C4)CC3)=NC(=NC2=C1)N1CCCN(C)CC1
Solubility Chemicals:
Soluble in DMSO (5 mg/ml) or 100% ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase: S. Kubicek, et al.; Mol. Cell 25, 473 (2007) | Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds: Y. Shi, et al.; Cell Stem Cell 3, 568 (2008) | Activation of pluripotency genes in human fibroblast cells by a novel mRNA based approach: J.R. Plews, et al.; PLoS One 5, e14397 (2010)
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