ODQ
| Code | Size | Price |
|---|
| AG-CR1-3500-M010 | 10 mg | £65.00 |
Quantity:
| AG-CR1-3500-M050 | 50 mg | £185.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
1H-[1,2,4]Oxadiazole[4,3-a]quinoxalin-1-one
Appearance:
White to pale yellow solid.
CAS:
41443-28-1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light.
Hazards:
H315, H319, H335
InChi:
InChI=1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H
InChiKey:
LZMHWZHOZLVYDL-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 41443-28-1. Formula: C9H5N3O2. MW: 187.2. Potent and highly selective, irreversible inhibitor of soluble guanylyl cyclase (sGC). The binding is competitive with nitric oxide (NO). Tool to elucidate the nitric oxide (NO)-cGMP pathway. Apoptosis inhibitor Inhibits growth and migration of prostate cancer cells independent of its effects on GMP levels.
MDL:
MFCD00792620
Molecular Formula:
C9H5N3O2
Molecular Weight:
187.2
Other data:
Store in the dark. Solutions may decompose slowly.
Package Type:
Vial
Precautions:
P261, P271, P280, P312
Product Description:
Potent and highly selective, irreversible inhibitor of soluble guanylyl cyclase (sGC). The binding is competitive with nitric oxide (NO) [1-5]. Tool to elucidate the nitric oxide (NO)-cGMP pathway [1-5]. Apoptosis inhibitor [6] Inhibits growth and migration of prostate cancer cells independent of its effects on GMP levels [6].
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
O=C1ON=C2C=NC3=CC=CC=C3N12
Solubility Chemicals:
Soluble in DMSO (at least 5 mg/ml), ethyl acetate or 100% ethanol (1.2 mg/ml); insoluble in water.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase: C.L. Boulton, et al.; Neuroscience 69, 699 (1995) | Novel guanylyl cyclase inhibitor, ODQ reveals role of nitric oxide, but not of cyclic GMP in endothelin-1 secretion: F. Brunner, et al.; FEBS Lett. 376, 262 (1995) | Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one: J. Garthwaite, et al.; Mol. Pharmacol. 48, 184 (1995) | Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase: A. Schrammel, et al.; Mol. Pharmacol. 50, 1 (1996) | Inhibition of Soluble Guanylate Cyclase by ODQ: Y. Zhao, et al.; Biochemistry 39, 10848 (2000) | cGMP-independent anti-tumour actions of the inhibitor of soluble guanylyl cyclase, ODQ, in prostate cancer cell lines: G. Haramis, et al.; Br. J. Pharmacol. 155, 804 (2008)
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