Reticulol
| Code | Size | Price |
|---|
| BVT-0011-C250 | 250 ug | £90.00 |
Quantity:
| BVT-0011-M001 | 1 mg | £180.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
6,8-Dihydroxy-7-methoxy-3-methyl-1H-isochromen-1-one
Appearance:
White to off-white solid.
CAS:
26246-41-3
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Hazards:
H302, H312, H319
InChi:
InChI=1S/C11H10O5/c1-5-3-6-4-7(12)10(15-2)9(13)8(6)11(14)16-5/h3-4,12-13H,1-2H3
InChiKey:
LREZRXWUEZCZRU-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 26246-41-3. Formula: C11H10O5. MW: 222.2. Isolated from Streptomyces sp. Antibiotic. Cyclic adenosine 3',5'-monophosphate phosphodiesterase and topoisomerase I (Topo I) inhibitor. Antitumor compound.
MDL:
MFCD11111617
Molecular Formula:
C11H10O5
Molecular Weight:
222.2
Package Type:
Plastic Vial
Precautions:
P270, P280, P301, P312, P302, P352, P312
Product Description:
Antibiotic. Cyclic adenosine 3',5'-monophosphate phosphodiesterase and topoisomerase I (Topo I) inhibitor. Antitumor compound. Potential antifood allergic agent. Decreased the rates of degranulation and histamine release.
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
COC1=C(O)C2=C(C=C(C)OC2=O)C=C1O
Solubility Chemicals:
Soluble in DMSO, acetone or dimethylformamide.
Source / Host:
Isolated from Streptomyces sp.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
References
Reticulol, a new metabolic isocoumarin: L.A. Mitscher, et al.; Experientia 20, 258 (1964) | Isocoumarins from Streptomyces mobaraensis: M.A.W. Eaton and D.W. Hutchinson; Tetrahedron Lett. 12, 1337 (1971) | Reticulol, an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase: Y. Furutani, et al.; J. Antibiot. 28, 558 (1975) | Biosynthetic studies of reticulol, an isocoumarin, by 13C-NMR spectroscopy: Y. Furutani, et al.; Agric. Biol. Chem. 41, 1581 (1977) | Inhibition of cyclic nucleotide phosphodiesterases by reticulol: Y. Furutani, et al.; Agric. Biol. Chem. 41, 1587 (1977) | Reticulol, an inhibitor of cyclic nucleotide phosphodiesterases: Y. Furutani, et al.; Agric. Biol. Chem. 41, 989 (1977) | Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. Lung metastasis inhibition by growth inhibition of melanoma: D.S. Lim, et al.; Chemotherapy 49, 146 (2003) | Topoisomerase I inactivation by reticulol and its in vivo cytotoxicity against B16F10 melanoma: D.S. Lim, et al.; Chemotherapy 49, 257 (2003) | An Efficient Synthesis of 8-Hydroxy-6,7-dimethoxy-3-methylisocoumarin (6-O-methylreticulol): A. Saeed and S. Ehsan; Chem. Heterocyc. Comp. 41, 1381 (2005) | Polyketides from the deep-sea-derived fungus Graphostroma sp. MCCC 3A00421 showed potent anti-food allergic activities: S. Niu, et al.; J. Agr. Food Chem. 14, 1369 (2018)
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