alpha-NETA
| Code | Size | Price |
|---|
| AG-CR1-0151-M005 | 5 mg | £50.00 |
Quantity:
| AG-CR1-0151-M025 | 25 mg | £165.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
2-(alpha-Naphthoyl)ethyltrimethylammonium iodide
Appearance:
White to off-white solid.
CAS:
31059-54-8
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light.
Hazards:
H315, H319, H335
InChi:
InChI=1S/C16H20NO.HI/c1-17(2,3)12-11-16(18)15-10-6-8-13-7-4-5-9-14(13)15;/h4-10H,11-12H2,1-3H3;1H/q+1;/p-1
InChiKey:
QZXMJYVXMZJOAO-UHFFFAOYSA-M
Long Description:
Chemical. CAS: 31059-54-8. Formula: C16H20INO. MW: 369.2. Potent fluorescent inhibitor of choline acetyltransferase. CMKLR1 antagonist. Inhibits chemerin-stimulated beta-arrestin2 association with CMKLR1, as well as chemerin-triggered CMKLR1+ cell migration. Aldehyde dehydrogenase 1 (ALDH1A1) antagonist.
MDL:
MFCD00209857
Molecular Formula:
C16H20INO
Molecular Weight:
369.2
Other data:
Handling Note:1. The product is not very stable in solution and should not be heated during dissolution. We recommend to use freshly prepared solutions.2. A stock solution in abs. methanol can be made. Further dilute the stock solution in aqueous buffers. If performing biological experiments, ensure the residual amount of methanol is insignificant (<0.1%), since it may have physiological effects at low concentrations.
Package Type:
Vial
Precautions:
P261, P280, P302, P352, P304, P340, P405
Product Description:
Potent fluorescent inhibitor of choline acetyltransferase. CMKLR1 antagonist. Inhibits chemerin-stimulated beta-arrestin2 association with CMKLR1, as well as chemerin-triggered CMKLR1+ cell migration. Aldehyde dehydrogenase 1 (ALDH1A1) antagonist.
Purity:
>97% (NMR)
Signal word:
Warning
SMILES:
[I-].C[N+](C)(C)CCC(=O)C1=C2C=CC=CC2=CC=C1
Solubility Chemicals:
Soluble in methanol or DMSO (3mg/ml). Sparingly soluble in water.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
2-(alpha-Naphthoyl)ethyltrimethylammonium iodide and its beta-isomer: new selective, stable and fluorescent inhibitors of choline acetyltransferase: B.V. Sastry, et al.; J. Pharmacol. Exp. Ther. 245, 72 (1988) | Relationships between chemical structure and inhibition of choline acetyltransferase by 2-(alpha-naphthoyl)ethyl trimethylammonium and related compounds: B.V. Sastry, et al.; Pharmacol. Res. Commun. 20, 751 (1988) | Regulation of the choline transport system in superfused microcarrier cultures of BeWo cells: B.M Eaton & S.R. Sooranna; Placenta 19, 663 (1998) | Eosinophil-induced release of acetylcholine from differentiated cholinergic nerve cells: D.A. Sawatzky, et al.; Am. J. Physiol. Lung Cell Mol. Physiol. 285, L1296 (2003) | A novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory disease: K.L. Graham, et al.; PLoS One 9, e112925 (2014)
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