Bisindolylmaleimide III
| Code | Size | Price |
|---|
| AG-CR1-0112-M001 | 1 mg | £60.00 |
Quantity:
| AG-CR1-0112-M005 | 5 mg | £160.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
BIM III
Appearance:
Red solid.
CAS:
137592-43-9
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C23H20N4O2/c24-10-5-11-27-13-17(15-7-2-4-9-19(15)27)21-20(22(28)26-23(21)29)16-12-25-18-8-3-1-6-14(16)18/h1-4,6-9,12-13,25H,5,10-11,24H2,(H,26,28,29)
InChiKey:
APYXQTXFRIDSGE-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 137592-43-9. Formula: C23H20N4O2. MW: 384.4. Potent and selective protein kinase C (PKC) inhibitor. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2).
MDL:
MFCD01076633
Molecular Formula:
C23H20N4O2
Molecular Weight:
384.4
Package Type:
Vial
Product Description:
Potent and selective protein kinase C (PKC) inhibitor [1-3]. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2) [4, 5].
Purity:
>98% (NMR)
SMILES:
NCCCN1C=C(C2=C1C=CC=C2)C1=C(C(=O)NC1=O)C1=CNC2=C1C=CC=C2
Solubility Chemicals:
Soluble in methanol or DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
References
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C: D. Toullec, et al.; J. Biol. Chem. 266, 15771 (1991) | Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides: P.D. Davis, et al.; J. Med. Chem. 35, 177 (1992) | Protein kinase C inhibitors; structure-activity relationships in K252c- related compounds: S. Fabre & M. Prudhomme; Bioorg. Med. Chem. 1, 193 (1993) | Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors: D. Brehmer, et al.; Mol. Cell Proteomics 3, 490 (2004) | An immuno-chemo-proteomics method for drug target deconvolution: C. Saxena, et al.; J. Proteome Res. 7, 3490 (2008)
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