Bisindolylmaleimide VIII . AcOH [Ro 31-7549]

RO 31-8220 and RO 31-7549 show improved selectivity for protein kinase C over staurosporine in macrophages: P. Dieter & E. Fitzke; BBRC 181, 396 (1991) | Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C: S.E. Wilkinson, et al.; Biochem. J. 294, 335 (1993) | Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction: R.A. Bit, et al.; J. Med. Chem. 36, 21 (1993) | Effects of the selective protein kinase C inhibitor, Ro 31-7549, on the proliferation of cultured mouse epidermal keratinocytes: W.B. Bollag, et al.; J. Invest. Dermatol. 100, 240 (1993) | Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases: T. Zhou, et al.; Nat. Med. 5, 42 (1999) | Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways: T. Ohtsuka & T. Zhou; J. Biol. Chem. 277, 29294 (2002) | Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors: D. Brehmer, et al.; Mol. Cell Proteomics 3, 490 (2004) | Different signaling pathways involved in glucose- and cell swelling-induced insulin secretion by rat pancreatic islets in vitro: Z. Bacova, et al.; Cell Physiol. Biochem. 16, 59 (2005)