Bisindolylmaleimide X . hydrochloride [Ro 31-8425]
| Code | Size | Price |
|---|
| AG-CR1-0113-M001 | 1 mg | £75.00 |
Quantity:
| AG-CR1-0113-M005 | 5 mg | £205.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Ro 31-8425; BIM X
Appearance:
Red solid.
CAS:
145317-11-9131848-97-0 (free base)
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C26H24N4O2.ClH/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30;/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32);1H
InChiKey:
IMBOYWXMTUUYGZ-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 145317-11-9131848-97-0 (free base). Formula: C26H24N4O2 . HCl. MW: 424.5 . 36.5. Selective protein kinase C (PKC) inhibitor. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2). Inhibits superoxide generation in human neutrophils.
MDL:
MFCD04972010
Molecular Formula:
C26H24N4O2 . HCl
Molecular Weight:
424.5 . 36.5
Package Type:
Vial
Product Description:
Selective protein kinase C (PKC) inhibitor [1-3]. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2) [3]. Inhibits superoxide generation in human neutrophils [1].
Purity:
>95% (HPLC)
SMILES:
CC(C)(C=C)C12CC3N(C1NC1=C2C=CC=C1)C(=O)C1CC2(C(NC4=C2C=CC=C4)N1C3=O)C(C)(C)C=C
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
References
A novel conformationally restricted protein kinase C inhibitor, Ro 31-8425, inhibits human neutrophil superoxide generation by soluble, particulate and post-receptor stimuli: R.E. Muid, et al.; FEBS Lett. 293, 169 (1991) | Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C: S.E. Wilkinson, et al.; Biochem. J. 294, 335 (1993) | Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors: D. Brehmer, et al.; Mol. Cell Proteomics 3, 490 (2004)
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