C646
| Code | Size | Price |
|---|
| AG-CR1-3508-M001 | 1 mg | £50.00 |
Quantity:
| AG-CR1-3508-M005 | 5 mg | £100.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
(E)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)-methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
Appearance:
Red solid.
CAS:
328968-36-1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS09
Handling Advice:
Keep under inert gas.Protect from light.
Hazards:
H410
InChi:
InChI=1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12+
InChiKey:
HEKJYZZSCQBJGB-XDHOZWIPSA-N
Long Description:
Chemical. CAS: 328968-36-1. Formula: C24H19N3O6. MW: 445.4. Reversible cell permeable p300/CBP histone acetyltransferase (HAT) inhibitor. Specific inhibition to p300 (86%) compared to N-acetyltransferase, PCAF, GCN5, Rtt109, Sas or MOZ histone acetyltransferases (<10%). Cell growth inhibitor in melanoma and non-small-cell-lung (NSCL) human cancer cell lines.
MDL:
MFCD01784780
Molecular Formula:
C24H19N3O6
Molecular Weight:
445.4
Package Type:
Vial
Precautions:
P273, P391, P501
Product Description:
Reversible cell permeable p300/CBP histone acetyltransferase (HAT) inhibitor. Specific inhibition to p300 (86%) compared to N-acetyltransferase, PCAF, GCN5, Rtt109, Sas or MOZ histone acetyltransferases (<10%). Cell growth inhibitor in melanoma and non-small-cell-lung (NSCL) human cancer cell lines.
Purity:
>98% (NMR)
Signal word:
Warning
SMILES:
CC1=NN(C(=O)C1=CC1=CC=C(O1)C1=CC(C)=C(C)C=C1[N+]([O-])=O)C1=CC=C(C=C1)C(O)=O
Solubility Chemicals:
Soluble in DMSO (10mg/ml).
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
References
Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor: E.M. Bowers, et al.; Chem. Biol. 17, 471 (2010) | HAT Trick: p300, Small Molecule, Inhibitor: M. Ott & E. Verdin; Chem. Biol. 17, 417 (2010) | Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetics remodeling and the expression of pluripotency-associated genes: P. Mali, et al.; Stem Cells 28, 713 (2010) | Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP: N.T. Crump, et al.; PNAS 108, 7814 (2011) | Paradoxical Enhancement of Fear Extinction Memory and Synaptic Plasticity by Inhibition of the Histone Acetyltransferase p300: R. Marek, et al.; J. Neurosci. 31, 7486 (2011) | Inhibition of the acetyltransferases p300 and CBP reveals a targetable function for p300 in the survival and invasion pathways of prostate cancer cell lines: F.R. Santer, et al.; Mol. Cancer Ther. 10, 1644 (2011)