Ds(+)-threo-Isocitric acid . trisodium salt
| Code | Size | Price |
|---|
| AG-CR1-3505-M025 | 25 mg | £60.00 |
Quantity:
| AG-CR1-3505-M100 | 100 mg | £160.00 |
Quantity:
| AG-CR1-3505-G001 | 1 g | £1,060.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
(1R,2S)-1-Hydroxy-1,2,3-propanetricarboxylic acid; (2R,3S)-Isocitric acid . trisodium salt
Appearance:
White to off-white solid.
CAS:
903507-52-8 | Free Acid: 6061-97-8
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Hygroscopic.Keep under inert gas.Protect from light.Protect from moisture and oxygen.
InChi:
InChI=1S/C6H8O7.3Na/c7-3(8)1-2(5(10)11)4(9)6(12)13;;;/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13);;;/q;3*+1/p-3
InChiKey:
HWMVXEKEEAIYGB-UHFFFAOYSA-K
Long Description:
Chemical. CAS: 903507-52-8. Formula: C6H5O7 . 3Na. MW: 189.1 . 69.0. Anticoagulant that retains platelets functionality. Buffers Ca2+ activity in physiological range (~1mM). Bypasses the metabolic blockade, may permit heme biosynthesis but does not suffice to reverse the iron-restriction response. Stabilizes the iron-sulfur cluster and is predicted to restore aconitase to its 'high iron' conformation and thereby dissociates the PKC-associated signaling complexes whose hyperactivation impairs Epo responsiveness. Binds IDH (isocitrate dehydrogenase), an excellent candidate for participating, along with aconitase and PKC, in an iron restriction signalosome. Contributes to heme biosynthesis which may account for its greater potency in restoring erythroid differentiation.
Molecular Formula:
C6H5O7 . 3Na
Molecular Weight:
189.1 . 69.0
Package Type:
Vial
Product Description:
Anticoagulant that retains platelets functionality. Buffers Ca2+ activity in physiological range (~1mM). Bypasses the metabolic blockade, may permit heme biosynthesis but does not suffice to reverse the iron-restriction response. Stabilizes the iron-sulfur cluster and is predicted to restore aconitase to its 'high iron' conformation and thereby dissociates the PKC-associated signaling complexes whose hyperactivation impairs Epo responsiveness. Binds IDH (isocitrate dehydrogenase), an excellent candidate for participating, along with aconitase and PKC, in an iron restriction signalosome. Contributes to heme biosynthesis which may account for its greater potency in restoring erythroid differentiation.
Purity:
>98% (NMR)
SMILES:
O[C@H]([C@H](CC(=O)O[Na])C(=O)O[Na])C(=O)O[Na]
Solubility Chemicals:
Soluble in water.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
References
Isocitrate as Calcium Ion Activity Buffer in Coagulation Assays: M. Ranby, et al.; Clin. Chem. 45, 1176 (1999) | Syntheses with a Chiral Building Block from the Citric Acid Cycle: (2R,3S)-Isocitric Acid by Fermentation of Sunflower Oil: P. Heretsch, et al.; Angew. Chem. Int. Ed. 47, 1958 (2008) | Cancer-associated IDH1 mutations produce 2-hydroxyglutarate: L. Dang, et al.; Nature 462, 739 (2009) | Iron control of erythroid development by a novel aconitase-associated regulatory pathway: G.C. Bullock, et al.; Blood 116, 97 (2010)