PD 98,059
| Code | Size | Price |
|---|
| AG-CR1-0118-M001 | 1 mg | £30.00 |
Quantity:
| AG-CR1-0118-M005 | 5 mg | £60.00 |
Quantity:
| AG-CR1-0118-M010 | 10 mg | £100.00 |
Quantity:
| AG-CR1-0118-M050 | 50 mg | £280.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
2'-Amino-3'-methoxyflavone
Appearance:
Yellow solid.
CAS:
167869-21-8
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light.
Hazards:
H302
InChi:
InChI=1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
InChiKey:
QFWCYNPOPKQOKV-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 167869-21-8. Formula: C16H13NO3. MW: 267.3. Highly selective, reversible and cell permeable MEK (MAP kinase kinase) inhibitor. Blocks the phosphorylation and activation of the MAP kinase pathway. T cell activation inhibitor. Inhibits cell growth and cell proliferation of several cancer cells.
MDL:
MFCD00671789
Molecular Formula:
C16H13NO3
Molecular Weight:
267.3
Package Type:
Vial
Precautions:
P270, P301, P312, P330
Product Description:
Highly selective, reversible and cell permeable MEK (MAP kinase kinase) inhibitor [1-3, 7]. Blocks the phosphorylation and activation of the MAP kinase pathway [1-3, 7]. T cell activation inhibitor [4]. Inhibits cell growth and cell proliferation of several cancer cells [5, 6, 8].
Purity:
>98% (NMR)
Signal word:
Warning
SMILES:
COC1=C(N)C(=CC=C1)C1=CC(=O)C2=CC=CC=C2O1
Solubility Chemicals:
Soluble in anhydrous DMSO, methanol or dichloromethane. Slightly soluble in ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
References
A synthetic inhibitor of the mitogen-activated protein kinase cascade: D.T. Dudley, et al.; PNAS 92, 7686 (1995) | Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor: L. Pang, et al.; J. Biol. Chem. 270, 13585 (1995) | PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo: D. Alessi, et al.; J. Biol. Chem. 270, 27489 (1995) | Inhibition of T cell activation by pharmacologic disruption of the MEK1/ERK MAP kinase or calcineurin signaling pathways results in differential modulation of cytokine production: F.J. Dumont, et al.; J. Immunol. 160, 2579 (1998) | A phosphatidylinositol 3-kinase inhibitor induces a senescent-like growth arrest in human diploid fibroblasts: M. Tresini, et al.; Cancer Res. 58, 1 (1998) | PD 098059, an inhibitor of ERK1 activation, attenuates the in vivo invasiveness of head and neck squamous cell carcinoma: C. Simon, et al.; Br. J. Cancer 80, 1412 (1999) | Specificity and mechanism of action of some commonly used protein kinase inhibitors. S.P. Davies, et al.; Biochem. J. 351, 95 (2000) | Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells: K. Kojima, et al.; Cancer Res. 67, 3210 (2007)