SANT-2
| Code | Size | Price |
|---|
| AG-CR1-3514-M001 | 1 mg | £45.00 |
Quantity:
| AG-CR1-3514-M005 | 5 mg | £95.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
Appearance:
White to off-white solid.
CAS:
329196-48-7
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light.
InChi:
InChI=1S/C26H26ClN3O4/c1-4-32-22-13-16(14-23(33-5-2)24(22)34-6-3)26(31)28-17-11-12-19(27)18(15-17)25-29-20-9-7-8-10-21(20)30-25/h7-15H,4-6H2,1-3H3,(H,28,31)(H,29,30)
InChiKey:
VQOJFGFKIVFMDH-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 329196-48-7. Formula: C26H26ClN3O4. MW: 480. Sonic hedgehog (Shh) signaling pathway modulator. Cell permeable potent smoothened (Smo) antagonist. Inhibits wt and oncogenic Smo. SAG activity (Prod. Nr. AG-CR1-3506) inhibitor. Gli1 reporter gene expression inhibitor. Suppresses the Shh-dependent translocation of Smo to the primary cilium. Potential tumor growth blocker.
MDL:
MFCD01827636
Molecular Formula:
C26H26ClN3O4
Molecular Weight:
480
Package Type:
Vial
Product Description:
Sonic hedgehog (Shh) signaling pathway modulator. Cell permeable potent smoothened (Smo) antagonist. Inhibits wt and oncogenic Smo. SAG activity (Prod. Nr. AG-CR1-3506) inhibitor. Gli1 reporter gene expression inhibitor. Suppresses the Shh-dependent translocation of Smo to the primary cilium. Potential tumor growth blocker.
Purity:
>95% (NMR)
SMILES:
CCOC1=CC(=CC(OCC)=C1OCC)C(=O)NC1=CC(C2=NC3=C(N2)C=CC=C3)=C(Cl)C=C1
Solubility Chemicals:
Soluble in DMSO, ethanol or chloroform.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
References
Small molecule modulation of Smoothened activity: J.K. Chen, et al.; PNAS 99, 14071 (2002) | Targeting the Hedgehog pathway in cancer: L.L. Rubin & F.J. de Sauvage; Nat. Rev. Drug. Discov. 5, 1026 (2006) (Review) | Evidence for allosteric interactions of antagonist binding to the smoothened receptor: C.M. Rominger, et al.; J. Pharmacol. Exp. Ther. 329, 995 (2009) | Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process: R. Rohatgi, et al.; PNAS 106, 3196 (2009) | Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway: A. B?ttner, et al.; Bioorg. Med. Chem. 17, 4943 (2009)
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