RO-3306
| Code | Size | Price |
|---|
| AG-CR1-3515-M001 | 1 mg | £40.00 |
Quantity:
| AG-CR1-3515-M005 | 5 mg | £90.00 |
Quantity:
| AG-CR1-3515-M025 | 25 mg | £250.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
(5Z)-2-((Thiophen-2-yl)methylamino)-5-((quinolin-6-yl)methylene)thiazol-4(5H)-one
Appearance:
Brown solid.
CAS:
872573-93-8
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light.
Hazards:
H315, H319, H335
InChi:
InChI=1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)/b16-10-
InChiKey:
XOLMRFUGOINFDQ-YBEGLDIGSA-N
Long Description:
Chemical. CAS: 872573-93-8. Formula: C18H13N3OS2. MW: 351.5. Selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Potential anti-cancer compound. Cell cycle arrest inducer at G1, S and G2/M . Apoptosis inducer in embryonic stem cells. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines. Suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387. Enhances Fas-mediated activation and processing of procaspase-8 in mitotic cells towards.
MDL:
MFCD17392573
Molecular Formula:
C18H13N3OS2
Molecular Weight:
351.5
Package Type:
Vial
Precautions:
P261, P271, P280, P312
Product Description:
Selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A) [1-3, 5]. Potential anti-cancer compound [1, 8]. Cell cycle arrest inducer at G1, S and G2/M [2, 7] . Apoptosis inducer in embryonic stem cells [4]. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines [6]. Suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387 [8, 9]. Enhances Fas-mediated activation and processing of procaspase-8 in mitotic cells towards [9].
Purity:
>95% (NMR)
Signal word:
Warning
SMILES:
O=C1N=C(NCC2=CC=CS2)SC1=C/C1=CC2=C(C=C1)N=CC=C2
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
References
Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1: L.T. Vassilev, et al.; PNAS 103, 10660 (2006) | Cell cycle synchronization at the G2/M phase border by reversible inhibition of CDK1: L.T. Vassilev; Cell Cycle 5, 2555 (2006) | Selective chemical inhibition as a tool to study Cdk1 and Cdk2 functions in the cell cycle: L. Krasinska, et al.; Cell Cycle 7, 1702 (2008) | Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity: Z. Ullah, et al.; Genes Dev. 22, 3024 (2008) | Cyclin A2-cyclin-dependent kinase 2 cooperates with the PLK1-SCFbeta-TrCP1-EMI1-anaphase-promoting complex/cyclosome axis to promote genome reduplication in the absence of mitosis: H.T. Ma, et al.; Mol. Cell Biol. 29, 6500 (2009) | Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML: K. Kojima, et al.; Cancer Sci. 100, 1128 (2009) | Differential roles of STIM1, STIM2 and Orai1 in the control of cell proliferation and SOCE amplitude in HEK293 cells: C. El Boustany, et al.; Cell Calcium 47, 350 (2010) | Restoration of the tumor suppressor p53 by downregulating cyclin B1 in human papillomavirus 16/18-infected cancer cells: N.N. Kreis, et al.; Oncogene 29, 5591 (2010) | Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity: Y. Matthess, et al.; Mol. Cell Biol. 30, 5726 (2010)