Sclerotiorin
Product Code: AG-CN2-0054
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0054-MC05 | 0.5 mg | £100.00 |
Quantity:
| AG-CN2-0054-M001 | 1 mg | £160.00 |
Quantity:
| AG-CN2-0054-M005 | 5 mg | £610.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
(S-(R*,R*-(E,E)))-Sclerotiorin
Appearance:
Yellow solid.
CAS:
549-23-5
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C21H23ClO5/c1-6-12(2)9-13(3)7-8-15-10-16-17(11-26-15)19(24)21(5,27-14(4)23)20(25)18(16)22/h7-12H,6H2,1-5H3/b8-7+,13-9+/t12-,21+/m0/s1
InChiKey:
SWJLTKXURNHVHE-UPWXJBBJSA-N
Long Description:
Chemical. CAS: 549-23-5. Formula: C21H23ClO5. MW: 390.9. Isolated from fungus Penicillium sp. Antibiotic. Antibacterial. Weak antagonist of human endothelin receptor A (ETA) and B (ETB). Cholesteryl ester transfer protein (CETP) activity inhibitor. Grb2-Shc binding inhibitor. Potent aldose reductase inhibitor. Potent reversible, non-competitive soybean lipoxygenase-1 (LOX-1) inhibitor. Antioxidant. Free radical scavenger. Antifungal.
MDL:
MFCD03427490
Molecular Formula:
C21H23ClO5
Molecular Weight:
390.9
Other data:
Solubility in aqueous buffers: Dissolve in DMF and then dilute with the aqueous buffer of choice. Sclerotiorin has a solubility of approx. 0.3mg/ml in a 1:2 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.
Package Type:
Vial
Product Description:
Antibiotic [4, 6, 7]. Antibacterial [4, 6, 7] with anticancer activity [8]. Weak antagonist of human endothelin receptor A (ETA) and B (ETB) [1]. Cholesteryl ester transfer protein (CETP) activity inhibitor [2]. Grb2-Shc binding inhibitor [3]. Potent aldose reductase inhibitor [4]. Potent reversible, non-competitive soybean lipoxygenase-1 (LOX-1) inhibitor [5]. Antioxidant. Free radical scavenger [5]. Antifungal [6, 7].
Purity:
>97% (HPLC)
SMILES:
CC[C@H](C)C=C(/C)C=CC1=CC2=C(Cl)C(=O)[C@](C)(OC(C)=O)C(=O)C2=CO1
Solubility Chemicals:
Soluble in DMSO, ethanol or DMF. Sparingly soluble in aqueous buffers.
Source / Host:
Isolated from fungus Penicillium sp.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Azaphilones with endothelin receptor binding activity produced by Penicillium sclerotiorum: taxonomy, fermentation, isolation, structure elucidation and biological activity: L. Pairet, et al.; J. Antibiot. (Tokyo) 48, 913 (1995) | Structure-specific inhibition of cholesteryl ester transfer protein by azaphilones: H. Tomoda, et al.; J. Antibiot. (Tokyo) 52, 160 (1999) | Sclerotiorin and isochromophilone IV: Inhibitors of Grb2-Shc interaction, isolated from Penicillium multicolor F1753: N. Ji-Youn, et al.; J. Microbiol. Biotechnol. 10, 544 (2000) | Sclerotiorin, from Penicillium frequentans, a potent inhibitor of aldose reductase: C. Chidananda, et al.; Biotechnol. Lett. 28, 1633 (2006) | Sclerotiorin, a novel inhibitor of lipoxygenase from Penicillium frequentans: C. Chidananda & A.P. Sattur; J. Agric. Food. Chem. 55, 2879 (2007) | Antimicrobial properties of sclerotiorin, isocHromophilone VI and pencolide, metabolites from a Brazilian cerrado isolate of Penicillium sclerotiorum van Beyma: E. M.F. Lucas, et al.; Braz. J. Microbiol. 38, 785 (2007) | Synthesis and antifungal activity of novel sclerotiorin analogues: L. Lin, et al.; J. Agric. Food Chem. 60, 4480 (2012) | Anticancer activity of sclerotiorin, isolated from an endophytic fungus Cephalotheca faveolata: P. Giridharan, et al.; Indian J. Exp. Biol. 50, 464 (2012)
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