Wogonin
Product Code: AG-CN2-0064
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0064-M005 | 5 mg | £70.00 |
Quantity:
| AG-CN2-0064-M025 | 25 mg | £250.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
WOG; 5,7-Dihydroxy-8-methoxyflavone; BRN 0287152
Appearance:
Yellow solid.
CAS:
632-85-9
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.Protect from light.
InChi:
InChI=1S/C16H12O5/c1-20-15-12(19)7-10(17)14-11(18)8-13(21-16(14)15)9-5-3-2-4-6-9/h2-8,17,19H,1H3
InChiKey:
XLTFNNCXVBYBSX-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 632-85-9. Formula: C16H12O5. MW: 284.3. Isolated from Scutellaria baicalensis Georgi. Anti-inflammatory. Increases nitric oxide (NO) production. Inhibits PGE2, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOS II). Antioxidant. Anti-viral. Shows anti-hepatitis B virus activity. MCP-1 inhibitor. Shows anxiolytic effect through modulation of the GABA(A) receptor complex. Antifungal. Neuroprotective. Anticancer compound. Apoptosis and cell cycle arrest inducer. Sensitizes TNFalpha- and TRAIL-induced apoptosis. Antiangiogenic. NF-kappaB inhibitor. Telomerase activity inhibitor. CDK9 inhibitor. PI3K-AKT pathway modulator. Autophagy inducer.
MDL:
MFCD00017736
Molecular Formula:
C16H12O5
Molecular Weight:
284.3
Package Type:
Vial
Product Description:
Anti-inflammatory. Increases nitric oxide (NO) production [1]. Inhibits PGE2, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOS II) [2, 5]. Antioxidant [3]. Anti-viral. Shows anti-hepatitis B virus activity [4]. MCP-1 inhibitor [6]. Shows anxiolytic effect through modulation of the GABA(A) receptor complex [7]. Antifungal [8]. Neuroprotective [9]. Anticancer compound. Apoptosis and cell cycle arrest inducer [10, 12, 14, 17, 18]. Sensitizes TNFalpha- and TRAIL-induced apoptosis [11, 12]. Antiangiogenic [13]. NF-kappaB inhibitor [15]. Telomerase activity inhibitor [16]. CDK9 inhibitor [19]. PI3K-AKT pathway modulator [20]. Autophagy inducer [21].
Purity:
>98% (HPLC)
SMILES:
COC1=C(O)C=C(O)C2=C1OC(=CC2=O)C1=CC=CC=C1
Solubility Chemicals:
Soluble in DMSO and methanol.
Source / Host:
Isolated from Scutellaria baicalensis Georgi.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Inhibitory effects of baicalein and wogonin on lipopolysaccharide-induced nitric oxide production in macrophages: I. Wakabayashi; Pharmacol. Toxicol. 84, 288 (1999) | Wogonin inhibits inducible prostaglandin E(2) production in macrophages: I. Wakabayashi & K. Yasui; Eur. J. Pharmacol. 406, 477 (2000) | Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin: D.E. Shieh, et al.; Anticancer Res. 20, 2861 (2000) | Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis: R.L. Huang, et al.; Planta Med. 66, 694 (2000) | Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide: Y.C. Chen, et al.; Biochem. Pharmacol. 61, 1417 (2001) | Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells: Y.L. Chang, et al.; Mol. Pharmacol. 60, 507 (2001) | Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi: K.M. Hui, et al.; Biochem. Pharmacol. 64, 1415 (2002) | Antifungal activity of wogonin: M. Pal, et al.; Phytother. Res. 17, 1215 (2003) | Neuroprotective effect of wogonin: potential roles of inflammatory cytokines: H.Z. Piao, et al.; Arch. Pharm. Res. 27, 930 (2004) | The anticancer activities of wogonin in murine sarcoma S180 both in vitro and in vivo: W. Wang, et al.; Biol. Pharm. Bull. 29, 1132 (2006) | Wogonin sensitizes resistant malignant cells to TNFalpha- and TRAIL-induced apoptosis: S.C. Fas, et al.; Blood 108, 3700 (2006) | Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells: D.H. Lee, et al.; Biochem. Pharmacol. 75, 2020 (2008) | Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2: N. Lu, et al.; Life Sci. 82, 956 (2008) | Wogonin induced differentiation and G1 phase arrest of human U-937 leukemia cells via PKCdelta phosphorylation: H.W. Zhang, et al.; Eur. J. Pharmacol. 591, 7 (2008) | Wogonin inhibits microglial cell migration via suppression of nuclear factor-kappa B activity: H.Z. Piao, et al.; Int. Immunopharmacol. 8, 1658 (2008) | Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells: S.T. Huang, et al.; Phytomedicine 17, 47 (2010) | Wogonin induces apoptosis by activation of ERK and p38 MAPKs signaling pathways and generation of reactive oxygen species in human breast cancer cells: J.S. Yu & A.K. Kim; Mol. Cells 31, 327 (2011) | Inhibitory effects of wogonin on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9: P. Chen, et al.; Toxicology 282, 122 (2011) | Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1: G. Polier, et al.; Cell Death Dis. 2, e182 (2011) | Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway: K.F. Huang, et al.; Int. Immunopharmacol. 12, 334 (2012) | Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells: S.E. Chow, et al.; J. Cell Biochem. 113, 3476 (2012)