Asiaticoside
Product Code: AG-CN2-0080
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0080-M010 | 10 mg | £65.00 |
Quantity:
| AG-CN2-0080-M050 | 50 mg | £230.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
Blastostimulina; Centelase; Emdecassol; Madecassol; Marticassol; FK1080; BRN 0078195; NSC 166062
Appearance:
White solid.
CAS:
16830-15-2
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.
InChi:
InChI=1/C48H78O19/c1-20-10-13-48(15-14-46(6)23(29(48)21(20)2)8-9-28-44(4)16-24(51)39(60)45(5,19-50)27(44)11-12-47(28,46)7)43(61)67-42-36(58)33(55)31(53)26(65-42)18-62-40-37(59)34(56)38(25(17-49)64-40)66-41-35(57)32(54)30(52)22(3)63-41/h8,20-22,24-42,49-60H,9-19H2,1-7H3/t20-,21+,22-,24-,25-,26-,27,28-,29,30+,31-,32-,33+,34-,35+,36-,37-,38-,39+,40-,41,42+,44+,45+,46-,47-,48+/m1/s1
InChiKey:
WYQVAPGDARQUBT-NXDSUYQXBS
Long Description:
Chemical. CAS: 16830-15-2. Formula: C48H78O19. MW: 959.1. Isolated from Centella asiatica. Antibacterial. Human collagen I synthesis inducer. Anti-wrinkle activity. Shows wound healing activity. Enhances normal human skin cell migration, attachment and growth. Suppresses collagen expression and TGF-beta/Smad signaling by inducing Smad7 and inhibiting TGF-betaRI and TGF-betaRII. Anti-inflammatory. Anti-gastric ulcer. Mitogen-activated protein kinases (MAPKs), nuclear factor-kappaB (NF-kappaB), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOSII) expression, production of serum tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6) inhibitor. Apoptosis inducer in cancer cells. Enhances antitumor activity of vincristine in cancer cells. Might be useful in cancer chemotherapy. Anxiolytic. Antidepressant-like activity. Hepatoprotective effects. CYP2C19 and CYP3A4 inhibitor. Neuroprotective. Antileishmanial activity. cPLA2 and sPLA2 inhibitor.
MDL:
MFCD31657273
Molecular Formula:
C48H78O19
Molecular Weight:
959.1
Package Type:
Vial
Product Description:
Antibacterial. Human collagen I synthesis inducer. Anti-wrinkle activity. Shows wound healing activity. Enhances normal human skin cell migration, attachment and growth. Suppresses collagen expression and TGF-beta/Smad signaling by inducing Smad7 and inhibiting TGF-betaRI and TGF-betaRII. Anti-inflammatory and antioxidant agent with anti-gastric ulcer activity. Mitogen-activated protein kinases (MAPKs), nuclear factor-kappaB (NF-kappaB), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOSII) expression, production of serum tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6) inhibitor. Anticancer agent. Shown to induce apoptosis and autophagy in cancer cells. Enhances antitumor activity of vincristine in cancer cells. Might be useful in cancer chemotherapy. Anxiolytic. Antidepressant-like activity. Hepatoprotective effects. CYP2C19 and CYP3A4 inhibitor. Neuroprotective. Antileishmanial activity. cPLA2 and sPLA2 inhibitor.
Purity:
>95% (NMR)
SMILES:
[H][C@]12CC=C3C4[C@@H](C)[C@H](C)CC[C@@]4(CC[C@@]3(C)[C@]1(C)CCC1[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]21C)C(=O)O[C@@H]1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](OC3O[C@H](C)[C@H](O)[C@@H](O)[C@@H]3O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O
Solubility Chemicals:
Soluble in ethanol, methanol or pyridine. Insoluble in water.
Source / Host:
Isolated from Centella asiatica.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica: A. Shukla, et al.; J. Ethnopharmacol. 65, 1 (1999) | In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins: J.H. Sampson, et al.; Phytomedicine 8, 230 (2001) | The healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats: C.L. Cheng, et al.; Life Sci. 74, 2237 (2004) | Inhibitory effects of Centella asiatica water extract and asiaticoside on inducible nitric oxide synthase during gastric ulcer healing in rats: J.S. Guo, et al.; Planta Med. 70, 1150 (2004) | Improving lip wrinkles: lipstick-related image analysis: J.S. Ryu, et al.; Skin Res. Technol. 11, 157 (2005) | Asiaticoside induces human collagen I synthesis through TGFbeta receptor I kinase (TbetaRI kinase)-independent Smad signaling: J. Lee, et al.; Planta Med. 72, 324 (2006) | Anxiolytic-like effect of asiaticoside in mice: S.W. Chen, et al.; Pharmacol. Biochem. Behav. 85, 339 (2006) | Effects of asiaticoside on the expression of Smad protein by normal skin fibroblasts and hypertrophic scar fibroblasts: S.H. Qi, et al.; Clin. Exp. Dermatol. 33, 171 (2008) | Antidepressant-like effect of asiaticoside in mice: X. Liang, et al.; Pharmacol. Biochem. Behav. 89, 444 (2008) | Protective effects of Asiaticoside on acute liver injury induced by lipopolysaccharide/D-galactosamine in mice: L. Zhang, et al.; Phytomedicine 17, 811 (2010) | Asiaticoside suppresses collagen expression and TGF-beta/Smad signaling through inducing Smad7 and inhibiting TGF-betaRI and TGF-betaRII in keloid fibroblasts: B. Tang, et al.; Arch. Dermatol. Res. 303, 563 (2011) | In vitro inhibitory effects of asiaticoside and madecassoside on human cytochrome P450: T. Winitthana, et al.; Toxicol. In Vitro 25, 890 (2011) | Asiaticoside: attenuation of neurotoxicity induced by MPTP in a rat model of Parkinsonism via maintaining redox balance and up-regulating the ratio of Bcl-2/Bax: C.L. Xu, et al.; Pharmacol. Biochem. Behav. 100, 413 (2012) | Asiaticoside induces tumour-necrosis-factor-alpha-mediated nitric oxide production to cure experimental visceral leishmaniasis caused by antimony-susceptible and -resistant Leishmania donovani strains: S.K. Bhaumik, et al.; J. Antimicrob. Chemother. 67, 910 (2012) | Inhibition of cPLA2 and sPLA2 activities in primary cultures of rat cortical neurons by Centella asiatica water extract: P.P. Defillipo, et al.; Nat. Prod. Commun. 7, 841 (2012) | Asiaticoside enhances normal human skin cell migration, attachment and growth in vitro wound healing model: J.H. Lee, et al.; Phytomedicine 19, 1223 (2012) | Antipyretic and Anti-inflammatory Effects of Asiaticoside in Lipopolysaccharide-treated Rat through Up-regulation of Heme Oxygenase-1: J. Wan, et al.; Phytother. Res. 27, 1136 (2013) | Neuroprotective effects of Asiaticoside: F.Y. Qi, et al.; Neural. Regen. Res. 9, 1275 (2014) | Asiaticoside attenuates the effects of spinal cord injury through antioxidant and anti?inflammatory effects, and inhibition of the p38?MAPK mechanism: Y. Luo, et al.; Mol. Med. Rep. 12, 8294 (2015) | Burn wound healing properties of asiaticoside and madecassoside: Q. Hou, et al.; Exp. Ther. Med. 12, 1269 (2016) | Effect of asiaticoside on endothelial cells in hypoxia?induced pulmonary hypertension: X. Wang, et al.; Mol. Med. Rep. 17, 2893 (2018) | Anti-inflammatory effect of asiaticoside on human umbilical vein endothelial cells induced by ox-LDL: L. Jing, et al.; Cytotechnology 70, 855 (2018) | Antitumor Activity of Asiaticoside Against Multiple Myeloma Drug-Resistant Cancer Cells Is Mediated by Autophagy Induction, Activation of Effector Caspases, and Inhibition of Cell Migration, Invasion, and STAT-3 Signaling Pathway: L. Yingchun, et al.; Med. Sci. Monit. 25, 1355 (2019)