Aurantimycin A
| Code | Size | Price |
|---|
| BVT-0398-M001 | 1 mg | £95.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C
Documents
Further Information
Appearance:
Off-white solid.
CAS:
162478-50-4
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Keep cool and dry.
Hazards:
H302, H312, H319
InChi:
InChI=1S/C38H64N8O14/c1-20(2)17-24-13-14-38(55,60-23(24)6)37(7,54)36(53)42-29-30(21(3)4)59-35(52)22(5)45(56)32(49)25-11-9-15-40-43(25)28(47)18-39-31(48)27(19-58-8)46(57)33(50)26-12-10-16-41-44(26)34(29)51/h20-27,29-30,40-41,54-57H,9-19H2,1-8H3,(H,39,48)(H,42,53)/t22-,23+,24+,25+,26-,27+,29+,30+,37+,38+/m1/s1
InChiKey:
JSVPJXYQXDNLRD-NSCUIBACSA-N
Long Description:
Chemical. CAS: 162478-50-4. Formula: C38H64N8O14. MW: 857. Isolated from Streptomyces aurantiacus JA 4570. Depsipeptide antibiotic. Active against Gram-positive bacteria. Cytotoxic agent. Nematocide activity. Antiulcer agent. Anti-inflammatory drug (C5a antagonist).
MDL:
MFCD08062296
Molecular Formula:
C38H64N8O14
Molecular Weight:
857
Package Type:
Plastic Vial
Precautions:
P270, P280, P301, P312, P302, P352, P312
Product Description:
Depsipeptide antibiotic. Active against Gram-positive bacteria. Cytotoxic agent. Nematocide activity. Antiulcer agent. Anti-inflammatory drug (C5a antagonist).
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
[H][C@@]12CCCNN1C(=O)CNC(=O)[C@H](COC)N(O)C(=O)[C@@]1([H])CCCNN1C(=O)[C@@H](NC(=O)[C@](C)(O)[C@]1(O)CC[C@@H](CC(C)C)[C@H](C)O1)[C@@H](OC(=O)[C@@H](C)N(O)C2=O)C(C)C
Solubility Chemicals:
Soluble in chloroform, dichloromethane or DMSO. Poorly soluble in water.
Source / Host:
Isolated from Streptomyces aurantiacus JA 4570.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
References
Aurantimycins, new depsipeptide antibiotics from Streptomyces aurantiacus IMET 43917: U. Graefe, et al.; J. Antibiot. 48, 119 (1995) | Formation of membrane pores by aurantimycins A and B, new lipopeptide antibiotics from Streptomyces aurantiacus: P. Grigoriev, et al.; Bioelectrochem. Bioenerget. 36, 57 (1995) | Pharmacological actions of a new synthetic cyclodepsipeptide, the A83586C-citropeptin hybrid, on complement C5a and G-proteins: E.-S. K. Assem, et al.; Inflamm. Res. 57, 21 (2008) | Aurantimycin resistance genes contribute to survival of Listeria monocytogenes during life in the environment: S. Hauf, et al.; Mol. Microbiol. 111, 1009 (2019)