VEGF 165 (human) (rec.)
| Code | Size | Price |
|---|
| AG-40T-0045-C005 | 5 ug | £180.00 |
Quantity:
| AG-40T-0045-C020 | 20 ug | £385.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Shipping:
Blue Ice
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
Vascular Endothelial Growth Factor; VEGF-A; VPF
Biological Activity:
The ED50 for stimulation of cell proliferation by human umbilical vein endothelial cells for VEGF 165 has been determined to be in the range of 1-4ng/ml.
EClass:
32160000
Form (Short):
liquid
Formulation:
Lyophilized.
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.For long term storage we recommend to add at least 0.1% human or bovine serum albumin.
Long Description:
Protein. Human VEGF 165 (165aa). Source: Sf9 cells. Lyophilized. Purity: >95% (SDS-PAGE). Human vascular endothelial growth factor (VEGF 165) is produced as a homodimer. It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. VEGF 165 is a specific mitogen for vascular endothelial cells and a strong angiogenic factor in vivo. In addition to its action as a mitogen it is a potent vascular permeability factor (VPF) in vivo. It is also a chemoattractant molecule for monocytes and endothelial cells. It induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels.
Molecular Weight:
~45kDa
NCBI, Uniprot Number:
P15692-4
Package Type:
Plastic Vial
Product Description:
Human vascular endothelial growth factor (VEGF 165) is produced as a homodimer. It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. VEGF 165 is a specific mitogen for vascular endothelial cells and a strong angiogenic factor in vivo. In addition to its action as a mitogen it is a potent vascular permeability factor (VPF) in vivo. It is also a chemoattractant molecule for monocytes and endothelial cells. It induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels.
Purity:
>95% (SDS-PAGE)
Sequence:
Human VEGF 165 (165aa).
Source / Host:
Sf9 cells
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C.
References
Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling: N.M.S. van den Akker, et al.; Cardiovasc. Res. 78, 366 (2008)