PLGF (human) (rec.)
| Code | Size | Price |
|---|
| AG-40T-0047-C005 | 5 ug | £235.00 |
Quantity:
| AG-40T-0047-C020 | 20 ug | £620.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Shipping:
Blue Ice
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
Placenta Growth Factor; PLGF-1; PLGF-131
Biological Activity:
Measured by its ability to bind to immobilized rhsFlt-1 in a functional ELISA. Recombinant human PLGF can bind to immobilized rhsFlt-1 (100ng/well) with a linear range at 0.5-10ng/ml.
EClass:
32160000
Form (Short):
liquid
Formulation:
Lyophilized.
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.
Long Description:
Protein. Human PLGF (131aa). Source: Sf9 cells. Lyophilized. Purity: >95% (SDS-PAGE). Human placenta growth factor-1 (PLGF-1; PLGF) binds to the receptor FLT1/VEGFR-1. It acts as a potent chemoattractant for monocytes and only as a very weak mitogen for some endothelial cell types. The physiological function in vivo is still controversial. In several reports it was shown not to be a potent mitogen for endothelial cells and not angiogenic in vivo by using different assays. It was shown that PLGF from cell culture supernatants was angiogenic in the CAM assay and in the rabbit cornea assay.
Molecular Weight:
~34kDa (dimer)
NCBI, Uniprot Number:
P49763
Package Type:
Plastic Vial
Product Description:
Human placenta growth factor-1 (PLGF-1; PLGF) binds to the receptor FLT1/VEGFR-1. It acts as a potent chemoattractant for monocytes and only as a very weak mitogen for some endothelial cell types. The physiological function in vivo is still controversial. In several reports it was shown not to be a potent mitogen for endothelial cells and not angiogenic in vivo by using different assays. It was shown that PLGF from cell culture supernatants was angiogenic in the CAM assay and in the rabbit cornea assay.
Purity:
>95% (SDS-PAGE)
Sequence:
Human PLGF (131aa).
Source / Host:
Sf9 cells
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C.
References
Autocrine activity of soluble Flt-1 controls endothelial cell function and angiogenesis: S. Ahmad, et al.; Vasc. Cell 3, 2011