Necrostatin-1
| Code | Size | Price |
|---|
| AG-CR1-2900-M005 | 5 mg | £45.00 |
Quantity:
| AG-CR1-2900-M025 | 25 mg | £115.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
Nec-1; MTH-Trp; MTH-DL-Tryptophan; Methyl-thiohydantoin DL-tryptophan; 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone
Appearance:
Off-white to yellow solid.
CAS:
4311-88-0
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep under inert gas.Protect from light.
InChi:
InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
InChiKey:
TXUWMXQFNYDOEZ-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 4311-88-0. Formula: C13H13N3OS. MW: 259.3. Competitive indoleamine 2,3-dioxygenase (IDO) inhibitor. Cell permeable, potent and selective necroptosis (a non-apoptotic form of programmed cell death) inhibitor. Showed neuroprotection in a murine model of ischemic brain injury in vivo. Selective and ATP-competitive receptor-interacting protein kinase 1 (RIPK1) inhibitor. Used in inflammatory and degenerative disease models to target RIPK1. Suppresses autophagy and apoptosis in murine brain injury models. Cardioprotective and neuroprotective.
MDL:
MFCD00056916
Molecular Formula:
C13H13N3OS
Molecular Weight:
259.3
Other data:
Note:1 Necrostatin-1 is sparingly soluble in aqueous buffers. For a maximum solubility in aqueous buffers, it should first be dissolved in DMF and then diluted with the aqueous buffer of choice. The solubility is approximately 0.5 mg/ml in a 1:1 solution of DMF:PBS (pH 7.2) using this method. We recommend to store aqueous solutions not longer than one day. Note:2 In solution the product slightly tautomerizes. In polar solvents there is more enol form while in non-polar solvents there is more keto form.
Package Type:
Vial
Product Description:
Competitive indoleamine 2,3-dioxygenase (IDO) inhibitor [1, 4, 9, 10]. Cell permeable, potent and selective necroptosis (a non-apoptotic form of programmed cell death) inhibitor [2, 5]. Showed neuroprotection in a murine model of ischemic brain injury in vivo [2, 3]. Selective and ATP-competitive receptor-interacting protein kinase 1 (RIPK1) inhibitor [6, 7]. Used in inflammatory and degenerative disease models to target RIPK1 [7, 9, 10]. Suppresses autophagy and apoptosis in murine brain injury models [8, 9]. Cardioprotective and neuroprotective [11-14].
Purity:
>98% (HPLC)
SMILES:
CN1C(=S)NC(CC2=CNC3=CC=CC=C23)C1=O
Solubility Chemicals:
Soluble in DMSO, ethanol or dimethylformamide.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C. Stock solutions are stable for at least 3 months when stored at -20°C.
References
Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy: A.J. Muller, et al.; Nat. Med. 11, 312 (2005) | Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury: A. Degterev, et al.; Nat. Chem. Biol. 1, 112 (2005) | Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells: X. Xu, et al.; J. Neurochem. 103, 2004 (2007) | Clinical aspects of indoleamine 2,3-dioxygenase (IDO)-initiated tryptophan metabolism: IDO is a target of drug discovery for various diseasea: O. Takikawa; Int. Congr. Ser. 1304, 290 (2007) | Chemical genetic approaches to probing cell death: B.R. Stockwell & N.M. Gangadhar; Curr. Opin. Chem. Biol. 11, 83 (2007) | Identification of RIP1 kinase as a specific cellular target of necrostatins: A. Degterev, et al.; Nat. Chem. Biol. 4, 313 (2008) | RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation: Y. Cho, et al.; PLoS One 6, e23209 (2011) | Necrostatin-1 suppresses autophagy and apoptosis in mice traumatic brain injury model: Y.Q. Wang, et al.; Neurochem. Res. 37, 1849 (2012) | Necrostatin-1 blocks both RIPK1 and IDO: consequences for the study of cell death in experimental disease models: P. Vandenabeele, et al.; Cell Death Differ. 20, 185 (2013) | Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase: A. Degterev, et al.; Cell Death Differ 20, 366 (2013) | Study of cardioprotective effects of necroptosis inhibitors on isolated rat heart subjected to global ischemia-reperfusion: Y.V. Dimitriev, et al.; Bull. Exp. Biol. Med. 155, 245 (2013) | Necroptosis inhibitor necrostatin-1 promotes cell protection and physiological function in traumatic spinal cord injury: Y. Wang, et al.; Neuroscience 266, 91 (2014) | Necrostatin-1 protection of dopaminergic neurons; J.R. Wu, et al.; Neural. Regen. Res. 10, 1120 (2015) | Protective role of necrostatin-1 in acute myocardial infarction: F. Carbone, et al.; Eur. J. Clin. Invest. 46, 99 (2016)
Related Products
| Product Name | Product Code | Supplier | MMG-0358 | AG-CR1-3630 | AdipoGen Life Sciences | Summary Details | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|