anti-NFATc1 pAb (IG-205)
| Code | Size | Price |
|---|
| AG-25T-0110-C050 | 50 ug | £330.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Functional Study
- Immunocytochemistry (ICC)
- Immunohistochemistry (IHC)
- Immunoprecipitation (IP)
- Western Blot (WB)
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Nuclear Factor of Activated T Cells; Cytoplasmic 1; NFAT Transcription Complex Cytosolic Component; NF-ATc1
Concentration:
500µg/ml
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In PBS containing 1mg/ml BSA and 0.02% sodium azide.
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
Recombinant N-terminal human NFATc1 fragment fused to a GST-tag.
Long Description:
Polyclonal Antibody. Recognizes all known human NFATc1 isoforms. Source: Rabbit. Applications: FUNC, ICC, IHC, IP, WB. Liquid. In PBS containing 1mg/ml BSA and 0.02% sodium azide. NFATc1 plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 or IL-4 gene transcription. It controls gene expression in embryonic cardiac cells. Regulates not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells.
NCBI, Uniprot Number:
O95644
Package Type:
Plastic Vial
Product Description:
NFATc1 plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 or IL-4 gene transcription. It controls gene expression in embryonic cardiac cells. Regulates not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells.
Purity:
Antigen affinity purified.
Source / Host:
Rabbit
Specificity:
Recognizes all known human NFATc1 isoforms.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.
References
Pim-1 kinase enhances NFATc activity and neuroendocrine functions in PC12 cells: M. Glazova, et al.; Mol. Brain Res. 138, 116 (2005) | Specific and redundant roles for NFAT transcription factors in the expression of mast cell-derived cytokines: M. Klein, et al.; J. Immunol. 177, 6667 (2006) | Epigenetic changes and suppression of the nuclear factor of activated T cell 1 (NFATC1) promoter in human lymphomas with defects in immunoreceptor signaling: A. Akimzhanov, et al.; Am. J. Pathol. 172, 215 (2008) | Cyclic AMP-induced Chromatin Changes Support the NFATc-mediated Recruitment of GATA-3 to the Interleukin 5 Promoter: S. Klein-Hessling, et al.; J. Biol. Chem. 283, 31030 (2008) | Stimulation of interleukin-13 expression by human T-cell leukemia virus type 1 oncoprotein Tax via a dually active promoter element responsive to NF-kappaB and NFAT: K. Silbermann, et al.; J. Gen. Virol. 89, 2788 (2008) | Sumoylation of the Transcription Factor NFATc1 Leads to Its Subnuclear Relocalization and Interleukin-2 Repression by Histone Deacetylase: A. Nayak, et al.; J. Biol. Chem. 284, 10935 (2009) | NFATc1 affects mouse splenic B cell function by controlling the calcineurin-NFAT signaling network: S. Bhattacharyya, et al.; J. Exp. Med. 208, 823 (2011) | NFATc1 induction in peripheral T and B lymphocytes: M. Hock, et al.; J. Immunol. 190, 2345 (2013) | An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development: A.K. Patra, et al.; Nat. Immunol. 14, 127 (2013)