anti-NFATc2 (human) pAb (IG-209)
| Code | Size | Price |
|---|
| AG-25T-0111-C020 | 20 ug | £480.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunocytochemistry (ICC)
- Immunoprecipitation (IP)
- Western Blot (WB)
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Nuclear Factor of Activated T Cells; Cytoplasmic 2; NF-ATc2; NF-ATp
Concentration:
200µg/ml
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In PBS containing 1mg/ml BSA and 0.02% sodium azide.
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
Recombinant full-length human NFATc2 fused to a GST-tag.
Long Description:
Polyclonal Antibody. Recognizes human NFATc2. Source: Rabbit. Applications: ICC, IHC, IP, WB. Liquid. In PBS containing 1mg/ml BSA and 0.02% sodium azide. NFATc2 plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. It promotes invasive migration through the activation of GPC6 expression and the WNT5A signaling pathway.
NCBI, Uniprot Number:
Q13469
Package Type:
Plastic Vial
Product Description:
NFATc2 plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. It promotes invasive migration through the activation of GPC6 expression and the WNT5A signaling pathway.
Purity:
Antigen affinity purified.
Source / Host:
Rabbit
Specificity:
Recognizes human NFATc2.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.
References
Specific and redundant roles for NFAT transcription factors in the expression of mast cell-derived cytokines: M. Klein, et al.; J. Immunol. 177, 6667 (2006) | Epigenetic changes and suppression of the nuclear factor of activated T cell 1 (NFATC1) promoter in human lymphomas with defects in immunoreceptor signaling: A. Akimzhanov, et al.; Am. J. Pathol. 172, 215 (2008) | Cyclic AMP-induced Chromatin Changes Support the NFATc-mediated Recruitment of GATA-3 to the Interleukin 5 Promoter: S. Klein-Hessling, et al.; J. Biol. Chem. 283, 31030 (2008) | NFAT but not NF-B is critical for transcriptional induction of the pro-survival gene A1 following igE receptor activation in mast cells: E. Ulleras, et al.; Blood 111, 3081 (2008) | Autoregulation of Th1-mediated inflammation by twist1: U. Niesner, et al.; J. Exp. Med. 205, 1889 (2008) | CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation: I. Zanoni, et al.; Nature 460, 264 (2009) | Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells: H. Flach, et al.; Immunity 33, 723 (2010) | NFATc1 affects mouse splenic B cell function by controlling the calcineurin-NFAT signaling network: S. Bhattacharyya, et al.; J. Exp. Med. 208, 823 (2011) | Transcription factor NFATc2 controls the emergence of colon cancer associated with IL-6-dependent colitis: K. Gerlach, et al.; Cancer Res. 72, 4340 (2012) | Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells: M. Vaeth, et al.; PNAS 109, 16258 (2012) | An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development: A.K. Patra, et al.; Nat. Immunol. 14, 127 (2013)