Amlexanox
| Code | Size | Price |
|---|
| AG-CR1-3579-M010 | 10 mg | £60.00 |
Quantity:
| AG-CR1-3579-M050 | 50 mg | £210.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid; AA 673; Amoxanox; CHX 3673
Appearance:
White to off-white solid.
CAS:
68302-57-8
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Hazards:
H302
InChi:
InChI=1S/C16H14N2O4/c1-7(2)8-3-4-12-9(5-8)13(19)10-6-11(16(20)21)14(17)18-15(10)22-12/h3-7H,1-2H3,(H2,17,18)(H,20,21)
InChiKey:
SGRYPYWGNKJSDL-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 68302-57-8. Formula: C16H14N2O4. MW: 298.3. Antiallergic. Anti-inflammatory. Antagonizes the angiogenic and mitogenic activity of FGF-1 through S100A13. Inhibits FGF-1 release. Binds to HSP90. Inhibits C-terminal chaperone activity. Induces an increase in nonsense-containing mRNAs amount in treated cells, leading to the synthesis of functional full-length proteins in an efficient manner. Selective inhibitor of TANK-binding Kinase 1 (TBK1) and IKKepsilon. Reversibly lowers weight and improves insulin sensitivity and reduces inflammation and attenuated hepatic steatosis in obese mices without affecting food intake.
MDL:
MFCD00864790
Molecular Formula:
C16H14N2O4
Molecular Weight:
298.3
Package Type:
Vial
Precautions:
P270, P301, P312, P330
Product Description:
Antiallergic [1,2]. Anti-inflammatory [2]. Antagonizes the angiogenic and mitogenic activity of FGF-1 through S100A13. Inhibits FGF-1 release [3, 5]. Binds to HSP90. Inhibits C-terminal chaperone activity [4]. Induces an increase in nonsense-containing mRNAs amount in treated cells, leading to the synthesis of functional full-length proteins in an efficient manner [6]. Selective inhibitor of TANK-binding Kinase 1 (TBK1) and IKKepsilon. Reversibly lowers weight and improves insulin sensitivity and reduces inflammation and attenuated hepatic steatosis in obese mices without affecting food intake [7].
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
CC(C)C1=CC2=C(OC3=C(C=C(C(O)=O)C(N)=N3)C2=O)C=C1
Solubility Chemicals:
Soluble in DMSO (10mg/ml) or dimethylformamide (15mg/ml). Insoluble in water.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Inhibition by amoxanox (AA-673) of the immunologically, leukotriene D4- or platelet-activating factor-stimulated bronchoconstriction in guinea pigs and rats: T. Saijo, et al.; Int. Arch. Allergy Appl. Immunol. 77, 315 (1985) | Mechanism of action of an antiallergic agent, amlexanox (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase: H. Makino, et al.; Int. Arch. Allergy Appl. Immunol. 82, 66 (1987) | Amlexanox reversibly inhibits cell migration and proliferation and induces the Src-dependent disassembly of actin stress fibers in vitro: M. Landriscina, et al.; J. Biol. Chem. 275, 32753 (2000) | Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanox: M. Okada, et al.; Biochem. J. 374, 433 (2003) | Molecular level interactions of S100A13 with amlexanox: inhibitor for formation of the multiprotein complex in the nonclassical pathway of acidic fibroblast growth factor: S.G. Rani, et al.; Biochemistry 49, 2585 (2010) | Rescue of nonsense mutations by amlexanox in human cells: S. Gonzalez-Hilarion, et al.; Orphanet. J. Rare Dis. 7, 58 (2012) | An inhibitor of the protein kinases TBK1 and IKK-epsilon improves obesity-related metabolic dysfunctions in mice: S.M. Reilly, et al.; Nat. Med. 19, 313 (2013)
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