FTY720 . HCl
| Code | Size | Price |
|---|
| AG-CR1-3587-M001 | 1 mg | £22.00 |
Quantity:
| AG-CR1-3587-M005 | 5 mg | £30.00 |
Quantity:
| AG-CR1-3587-M025 | 25 mg | £50.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol . HCl; Fingolimod; Gilenya
Appearance:
White solid.
CAS:
162359-56-0
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Keep cool and dry.
Hazards:
H302, H332
InChi:
InChI=1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H
InChiKey:
SWZTYAVBMYWFGS-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 162359-56-0. Formula: C19H33NO2 . HCl. MW: 307.4 . 36.5. Synthetic analog of ISP-1, isolated from Isaria sinclairii. Cell permeable immunosuppressor displaying lymphocyte sequestration properties and used for treatment in multiple sclerosis. Potent sphingosine 1-phosphate (S1P) receptor (S1P1, S1P3, S1P4, and S1P5) agonist when phosphorylated by sphingosine kinase. Sphingosine transporter Abcb1 and leukotriene C4 transporter Abcc1 activity enhancer. Cytosolic phospholipase A2 inhibitor, independent of sphingosine 1-phosphate receptors. Autophagy inducer. Apoptosis inducer.
MDL:
MFCD00939512
Molecular Formula:
C19H33NO2 . HCl
Molecular Weight:
307.4 . 36.5
Package Type:
Vial
Precautions:
P261, P271, P301, P312, P304, P340
Product Description:
Cell permeable immunosuppressor displaying lymphocyte sequestration properties and used for treatment in multiple sclerosis. Potent sphingosine 1-phosphate (S1P) receptor (S1P1, S1P3, S1P4, and S1P5) agonist when phosphorylated by sphingosine kinase. Sphingosine transporter Abcb1 and leukotriene C4 transporter Abcc1 activity enhancer. Cytosolic phospholipase A2 inhibitor, independent of sphingosine 1-phosphate receptors. Shown to induce autophagy and apoptosis.
Purity:
>98%
Signal word:
Warning
SMILES:
[Cl-].CCCCCCCCC1=CC=C(CCC([NH3+])(CO)CO)C=C1
Solubility Chemicals:
Soluble in DMSO, ethanol or DMF.
Source / Host:
Synthetic analog of ISP-1, isolated from Isaria sinclairii.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
FTY720: Altered lymphocyte traffic results in allograft protection: V. Brinkmann, et al.; Transplantation 72, 764 (2001) | The immune modulator FTY720 targets sphingosine 1-phosphate receptors: V. Brinkmann, et al.; J. Biol. Chem. 277, 21453 (2002) | FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes: S.M. Honig, et al.; J. Clin. Invest. 111, 627 (2003) | Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1: M. Matloubian, et al.; Nature 427, 355 (2004) | The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors: S.G. Payne, et al.; Blood 109, 1077 (2007) | Fingolimod (FTY720): a recently approved multiple sclerosis drug based on a fungal secondary metabolite: C.R. Strader, et al.; J. Nat. Prod. 74, 900 (2011) | Autophagy induced by FTY720 promotes apoptosis in U266 cells: A. Liao, et al.; Eur. J. Pharm. Sci. 45, 600 (2012) | Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma: A. Estrada-Bernal, et al.; Neuro Oncol. 14, 405 (2012) | T resident helper cells promote humoral responses in the lung: N. Swarnalekha, et al.; Sci. Immunol. 6, eabb6808 (2021) [in vivo application]