Altenusin

AdipoGen Life Sciences
Product Code: AG-CN2-0143
CodeSizePrice
AG-CN2-0143-M0011 mg£140.00
Quantity:
AG-CN2-0143-M0055 mg£490.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C

Images

1 / 1
Chemical Structure

Chemical Structure

Further Information

Alternate Names/Synonyms:
MS 341
Appearance:
Yellow solid.
CAS:
31186-12-6
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light.
Hazards:
H302, H312, H319
InChi:
InChI=1S/C15H14O6/c1-7-3-11(16)12(17)6-9(7)10-4-8(21-2)5-13(18)14(10)15(19)20/h3-6,16-18H,1-2H3,(H,19,20)
InChiKey:
ADPBTBPPIIKLEH-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 31186-12-6. Formula: C15H14O6. MW: 290.3. Isolated from Penicillium sp. Antibiotic. Antifungal penicillide. Non-competitive, specific neutral sphingomyelinase (N-SMase) inhibitor. Strong pp60c-Src inhibitor. Inhibits cFMS receptor tyrosine kinase (CSF-1/m-CSF receptor tyrosine kinase) which is implicated in cancer and bone diseases. Myosin light chain kinase inhibitor. Exhibits anti-HIV-1 integrase activity. Cytotoxic activity against mouse lymphoma cells. Anti-protozoan, trypanothione reductase (TR) inhibitor. Phytotoxin.
MDL:
MFCD14635401
Molecular Formula:
C15H14O6
Molecular Weight:
290.3
Package Type:
Vial
Precautions:
P270, P280, P301, P312, P302, P352, P312
Product Description:
Antibiotic [7]. Antifungal penicillide [8]. Non-competitive, specific neutral sphingomyelinase (N-SMase) inhibitor [2]. Strong pp60c-Src inhibitor [3]. Inhibits cFMS receptor tyrosine kinase (CSF-1/m-CSF receptor tyrosine kinase) which is implicated in cancer and bone diseases [3]. Myosin light chain kinase inhibitor [1]. Exhibits anti-HIV-1 integrase activity [4]. Cytotoxic activity against mouse lymphoma cells [6]. Anti-protozoan, trypanothione reductase (TR) inhibitor [5]. Phytotoxin [9].
Purity:
>97% (HPLC)
Signal word:
Warning
SMILES:
COC1=CC(O)=C(C(O)=O)C(=C1)C1=CC(O)=C(O)C=C1C
Solubility Chemicals:
Soluble in methanol, ethanol or DMSO.
Source / Host:
Isolated from Penicillium sp.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

Isolation of myosin light chain kinase inhibitors from microorganisms: dehydroaltenusin, altenusin, atrovenetinone, and cyclooctasulfur: S. Nakanishi, et al.; Biosci. Biotechnol. Biochem. 59, 1333 (1995) | Alutenusin, a specific neutral sphingomyelinase inhibitor, produced by Penicillium sp. FO-7436: R. Uchida, et al.; J. Antibiot. 52, 572 (1999) | Fungal Metabolites as Potent Protein Kinase Inhibitors: Identification of a Novel Metabolite and Novel Activities of Known Metabolites: M. Oyama, et al.; Lett. Drug Des. Disc. 1, 24 (2004) | HIV-1 Integrase Inhibitors: 2003-2004 Update: R. Dayan, et al.; Med. Res. Rev. 26, 271 (2006) | Altenusin, a biphenyl isolated from the endophytic fungus Alternaria sp. inhibits trypanothione reductase from Trypanosoma cruzi: B.B. Cota, et al.; FEMS Microbiol. Lett. 285, 177 (2008) | Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense: A.H. Aly, et al.; J. Nat. Prod. 71, 972 (2008) | Polyketides with antimicrobial activity from the solid culture of an endolichenic fungus Ulocladium sp.: Q.X. Wang, et al.; Fitoterapia 83, 209 (2012) | Antifungal activity of altenusin isolated from the endophytic fungus Alternaria sp. against the pathogenic fungus Paracoccidioides brasiliensis: S. Johann, et al.; Rev. Iberoam. Micol. 29, 205 (2012) | Identification of Alternaria alternata mycotoxins by LC-SPE-NMR and their cytotoxic effects to soybean (Glycine max) cell suspension culture: G.D. de Souza, et al.; Molecules 18, 2528 (2013)

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